Design and Evaluation of Mouth Dissolving Tablet of Zopiclone using Different Superdisintegrants
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
In the present work, Mouth dissolving tablet of Zopicolon were designed with a view to Enhance patient compliance. A combination of super-disintegrants i.e.Ac-di-sol (Croscarmellose sodium), Polyplasdone XL-10, Microcrystalline Cellulose pH 102 was Used along with directly compressible dextrose to enhance mouth feel. The prepared Batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time, two formulation were tested for in vitro drug release pattern (in pH7.4 phosphatebuffer), short – term stability at 250 C 20 C/60% RH, 300 C 20 C/65% RH, 400 C 20 C/75% RH for 3 month and drug –excipient interaction (IR Spectroscopy) among the two formulation, the formulation prepared by direct Compression method using Ac-di-sol (croscarmellose sodium) 50mg, Polyplasdone XL- 10 -25mg, Microcrystalline Cellulose pH 102- 25mg was found tobe better formulation T80%= 5 min. based on in- vitro drug release characteristics. Short term stability studies on the formulation indicated that there is no significant change in drug content and in vitro dispersion time
Authors and Affiliations
D. G. Umalkar , B. Stephen Rathinaraj , G. S. Bangale , G. V. Shinde , D. Kumaraswamy , Ch. Rajveer , KS. Rajesh
Keywords
Related Articles
- EP ID EP102596
- DOI -
- Views 129
- Downloads 0
Management of Burns
Burns inflict serious injuries both psychologically and physically as a consequence of deformity and disfiguration (scarring) which is the most obvious and most probable outcome of burn injury. Thus the major challenge e...
Investigation of the effects of different physicochemical parameters on in vitro release kinetics of theophylline from Eudragit NE 30 and Eudragit RS 30D matrix tablets
The present study was considered out to investigate the effects of various physicochemical factors such as compression force, pH of dissolution medium, amount of HPMC (hydroxyl propyl methyl cellulose) on Eudragit NE 30D...
Anti-Hyperglycemic And Antidyslipidemic Potential Of Azadirachta indica Leaf Extract In STZ- Induced Diabetes Mellitus
Azadirachta indica , an Indian medicinal plant, has been studied for its role in diabetes and its effect on lipid profile. This study was conducted to elucidate whether treatment of Azadirachta indica leaf extract afte...
Design, Synthesis and Antiinflammatory Activity of Novel gamma Tocopherol Naproxen Ester Prodrug.
Naproxen is widely used for the treatment of arthritic pain. It can induce gastrointestinal (GI) side effects ranging from stomach irritation to ulceration and bleeding. These complications are believed to be deter...
PREPARATION AND EVALUATION OF TERNARY MIXING ITRACONAZOLE SOLID DISPERSIONS BY SPRAY DRYING METHOD
The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drugby spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibilit...