DESIGN AND EVALUATION OF SUSTAINED RELEASE CAPSULE FOR ACETAZOLAMIDE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 5
Abstract
The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. Acetazolamide is an inhibitor of carbonic anhydrase and is used mainly in the management of glaucoma. It is also used in the treatment of various forms of epilepsy, to prevent or ameliorate the symptoms of acute high altitude sickness and in the promotion of diuresis in instances of abnormal fluid retention, for example, cardiac edema. Acetazolamide is a drug having a shorter half-life of 4 hours. Hence, in present study we have prepared a sustained release capsule of Acetazolamide by using various polymers like HPMC K100M, Eudragit NE30D, HPMC K4M, MCC PH101, ethyl cellulose, carbopol 971P. Matrix embedding method was adopted to formulate sustained release capsule of acetazolamide. The formulation with 8.01% HPMC K100M, 0.68% talc and 4.18% Eudragit NE 30D coating was consider as a best product with respect to in-vitro drug release study.
Authors and Affiliations
Ishan Patel*| Department of Pharmaceutical science, Jaipur National University, SADTM Campus, Jaipur, India-302025., Ajay Kumar Tiwari| Department of Pharmaceutical science, Jaipur National University, SADTM Campus, Jaipur, India-302025., B. S. Srivastav| Department of Pharmaceutical science, Jaipur National University, SADTM Campus, Jaipur, India-302025.
Keywords
Related Articles
- EP ID EP1389
- DOI -
- Views 478
- Downloads 33
Life threatening ventilatory obstruction due to a foreign body in a new sealed endotracheal tube
In the current days of high tech equipment and well defined safety regulations, technical failures are less likely to occur. Still many manufacturing and packaging errors are encountered in anaesthetic practice which go...
ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF GRANGEA MADERASPATANA (L.) POIR. EXTRACT
The extract of aerial parts of Grangea maderaspatana (L.) Poir., obtained by steam distillation was analyzed by gas chromatography and gas chromatography coupled with mass spectroscopy. Twenty one constituents were ident...
Vitilego Cure by Homoeopathy
Vitiligo known as leucoderma is a relatively common skin disorder, in which white spots or patches appear on the skin. These spots are caused by destruction or weakening of the pigment cells in those areas, resulting in...
Planning social mobilization and communication for Dengue Hemorrhagic fever Diagnosis, Treatment, Prevention and Control: A step‑by‑step guide
Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases. Each year, there are ~50 million dengue infections and ~500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly...
Comparative HPTLC analysis and invitro antioxidant study of Cinnamomum zeylanicum.
Cinnamon (Cinnamomum zeylanicum, Family: Lauraceae) is one of the world's oldest spices. The cinnamon, also known by Cassia, Sweet Wood, and Gui Zhi, is traditionally harvested in Asian countries. It is, perhaps, one of...