DESIGN AND IN VIVO EVALUATION OF CONTROLLED RELEASE GLICLAZIDE TRILAYER MATRIX TABLETS IN THE MANAGEMENT OF DIABETES MELLITUS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 5
Abstract
The purpose of the present study was to develop and optimize multi-layered matrix tablets of Gliclazide trilayer tablets to achieve zero-order drug release for sustained plasma concentration. Gliclazide tablets were prepared by direct compression and consist of middle active layer with different grades of hydroxypropyl methylcellulose (HPMC K 4M, K 15M and K100M), Guar gum and Eudragit L 100. The tablets were also evaluated for physicochemical characteristics and release kinetics. The physicochemical characteristics of the prepared tablets were satisfactory. The developed drug delivery systems showed prolonged drug release rates over a period of 24 h. In vivo bioavailability studies were carried out on the optimized formulation (EF14), mean time to attain peak drug concentration (Tmax) was 6.00 ± 0.14 and 4.02 ± 0.12 h for the optimized and marketed product respectively, while mean maximum drug concentration (Cmax) was 124.80 ± 1.02 ng/ml and 95.12 ± 1.05 ng/ml respectively. AUC0-α and AUC0-t for optimized formulation was significantly higher (p<0.05) as compared to marketed product. A fair correlation between the dissolution profile and bioavailability for the optimized formulation was observed. The results indicate that the approach used could lead to a successful development of a controlled release formulation of the drug. The EF14 was shown significant plasma concentration with controlled release and maintained for 24 hours with patient compliance by reducing the dosage frequency, when compared with marketed product in the efficient management of Diabetes mellitus.
Authors and Affiliations
B. Ram Prasad, D. V. R. N. Bhikshapathi
Keywords
Related Articles
- EP ID EP622224
- DOI 10.25004/IJPSDR.2018.100508
- Views 88
- Downloads 0
SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL 2-[(5-ARYL)-4, 5-DIHYDRO-1H-PYRAZOLE-3-YL]-1H-BENZIMIDAZOLES WITH ANTIMICROBIAL ACTIVITY
A novel series of 4-(1H-benzo[d]imidazol-2-yl)-6-phenyl-2-pyrimidinamines (6a-h) have been synthesized in good to excellent yields by using commercially available o-phenylenediamine (o-PDA) (1a-d) and α-hydroxy propionic...
A STUDY OF ANALGESIC AND ANTIMICROBIAL POTENTIAL OF MITRAGYNA PARVIFOLIA
The present study was designed to evaluate the analgesic and antimicrobial activities of ethanolic extract of leaves ofMitragyna parvifolia plant (Rubiaceae) family. The analgesic activity was carried out on swiss albino...
FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF ENTACAPONE SOLID DISPERSIONS WITH LIPID CARRIERS BY USING SPRAY DRYING METHOD
In present study, immediate release solid dispersion formulation of Entacapone with various lipids was developed using spray drying method. Entacapone is indicated for the treatment of Parkinson’s disease (PD) as an adju...
Formulation and Evaluation of Solid Dispersion Incorporated Fast Disintegrating Tablets of Tenoxicam Using Design of Experiment
The aim of the present work is to develop fast dissolving tablets from the solid dispersion of Tenoxicam for enhancement of solubility. The solid dispersions of Tenoxicam were prepared with Kollidon CL, PVP K30 and Polox...
EVALUATION OF EFFICACY AND SAFETY OF ARTEMISININ DERIVATIVES FOR TREATMENT OF SEVERE MALARIA: A META-ANALYSIS APPROACH
Despite progress in antimalarial management and intensive care, the prevalence of malaria is growing and the mortality rate is very high. Yet even with timely treatment of quinine in maximum doses, the death in patients...