Design and Optimizing of Metformin and 5-Fluorouracil Co-Loaded Nano Spheres by Box-Behnken Experimental Design for the Treatment of Colorectal Cancer
Journal Title: International Journal of Current Science Research and Review - Year 2024, Vol 7, Issue 07
Abstract
Aim and objective of the study was to design and optimize metformin and 5-Fluorouracil drug molecules co-loaded with chitosan biodegradable polymer Nano-spheres for effectively targeting colorectal cancer cells in chemically induced colorectal cancer models. The metformin and 5- fluorouracil loaded chitosan nanoparticles were formulated by ionotropic crosslinking method. Experimental design consisted of three independent variables: chitosan, tripolyphosphate and stirring speed and three dependent variables: particle size, entrapment efficiency and drug release using Box-Behnken experimental design. Response surface modelling and the ability to fit to the model were evaluated with Design-Expert® software (Version 12). The optimized formulation by the design software indicated 1.33% of chitosan, 0.715 % of TPP at a Stirring speed of 3383 rpm is recommend to achieve a desirability value of 0.813 to have an acceptable range of 0.8 to 1, suggesting that the formulation quality is acceptable and excellent.
Authors and Affiliations
Bharathi Priya K, Kulathuran Pillai K, Nalini CN, Ubaidulla Udhumansha,
Keywords
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- EP ID EP739988
- DOI 10.47191/ijcsrr/V7-i7-16
- Views 41
- Downloads 0
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