Design of Peptide Models for β-Hairpins and Equilibrating Helix-Hairpin Structures
Journal Title: International Journal of Nanomaterials, Nanotechnology and Nanomedicine - Year 2016, Vol 2, Issue 1
Abstract
It is well established that synthetic peptides containing a centrally positioned Type-I or Type-II β-turn can form well folded peptide hairpins (1). Earlier studies from this laboratory have established that D-Pro-Xxx segments nucleate β-hairpin structures, with formation of a central Type-II β-turn (2). The octapeptide (Boc-Leu-Phe-Val-Aib-D-Ala-Leu-Phe- Val-OMe) is a rare example of a synthetic peptide hairpin, containing a central Type-I β-turn. Hairpins with Type-I turns are considerably more twisted than their Type-II counterparts. The Aib-Xxx segment has also been shown to adopt a Type-I β-turn structure, resulting in incorporation into the centre of a long synthetic, helical peptide (3) (Figures 1,2).
Authors and Affiliations
Selvakkumar Chinnasamy, Reddy Eashwarwark Vikram, Selvarajan Kesavanarayanan Krishnan, Rahamuthullah Nazeerullah, Zarmouh Muftha Mohamed
Keywords
Related Articles
- EP ID EP335383
- DOI 10.17352/2455-3492.000009
- Views 98
- Downloads 0
Preparation of nanocellulose and its potential application
Nanostructured cellulose has received tremendous attention due to its inherent unique properties such as high strength, high surface area, flexible surface chemistry, abundant and renewable. The early polymers industry w...
Surface Enhanced Raman Scattering Spectroscopy for Pharmaceutical Determination
The rapid growth of pharmaceutical industries worldwide demands continuous development of efficient analytical techniques that help not only to detect the presence of the molecules at extremely low concentration levels,...
Synthesis, Characterization and Antibacterial Activity of Ciprofloxacin Loaded Polymer Nanoparticles for Parenteral Application
Different polymerization techniques as particle formation processes for ciprofloxacin-loaded poly (butyl cyanoacrylate) nanoparticles (CfH-PBCN) were evaluated to choose the most appropriate in terms of the resulting nan...
Need to Explore Nanodelivery of Stem Cells with Multimodal Drug like Cerebrolysin for Effective Strategies for Enhanced Neuroprotection and Neurorecovery in Neurodegenerative Disorders
Central nervous system (CNS) is vulnerable to various kinds of physical, chemical, metabolic or age-related insults leading to neurodegeneration. Neurodegenerative diseases either caused by aging or following trauma to t...
Highly Monodisperse Chitosan Nanoparticles Prepared by a Combined Triple-Method for Potential Use as Drug Carriers
Chitosan (CS) as a biodegradable polymer with unique bio-attachment properties that makes it favorable to be used in biomedical applications. Insolubility in water is the problem with use of CS. The purpose of this study...