DESIGN, SYNTHESIS AND ANTIEPILEPTIC EVALUATION OF 5-(ARYL)-N-PHENYL-1,3,4-THIADIAZOL-2-AMINE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2012, Vol 4, Issue 3
Abstract
Epilepsy is one of the leading neurological disorders, which is a major threat to public health. Though, several new antiepileptic drugs are developed, the treatment of epilepsy remains still inadequate, and the patient suffers from a lot of side effects. Therefore, it is essential to search for newer chemical entities for the treatment of epilepsy. So here an indirect type of molecular modeling study was carried out to find out the 3D structural similarity between some reported antiepileptic drugs and the newly designed 1,3,4-thiadiazole derivatives. Thus, a new series of 1,3,4-thiadiazole derivatives were synthesized by cyclization of N-phenylthiosemicarbazide with various aromatic acids. Both conventional and microwave irradiated synthesis of 1,3,4-thiadiazole derivatives have been carried out to compare their yield and reaction time. Microwave technology enables the reaction to be simple, rapid, high yielding with at most pure and led environmentally benign synthesis. All the newly synthesized compounds were characterized by I.R, 1H NMR, and LC-MASS and also evaluated for their antiepileptic activity by MES model in rats.
Authors and Affiliations
BISWA MOHAN SAHOO , S. C. DINDA , B. V. V. RAVI KUMAR
Keywords
Related Articles
- EP ID EP125052
- DOI -
- Views 149
- Downloads 0
A RAPID RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF EPLERENONE IN TABLETS
Objective: To develop a rapid, sensitive, accurate, precise, linear and rugged Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method and validate as per ICH guidelines for the quantitative estimation of...
STUDIES ON KINETIC PARAMETERS AND BIOCHEMICAL CHARACTERISTICS OF POLYPHENOL OXIDASE PURIFIED FROM JACKFRUIT (ARTOCARPUS HETEROPHYLLUS) WASTE
Objectives: Polyphenol oxidase activity was extensively studied in jackfruit for its role in enzymatic browning. PPO and the phenolic compound play a vital role in defensive mechanism against pest and diseases. Thus, to...
ISOLATION, SCREENING AND CHARACTERIZATION OF L-ASPARAGINASE PRODUCING FUNGI FROM MEDICINAL PLANTS
Objective: To isolate and characterize of L-asparaginase producing fungi from medicinal plants.Methods: Fungal strains were isolated on standard media, characterized and were screened for their ability to produce L-aspar...
IN SILICO MODELLING OF β-LACTAM RESISTANT ENTEROCOCCUS FAECALIS PBP4 AND ITS INTERACTIONS WITH VARIOUS PHYTO-LIGANDS
Objective: The resistance to β-lactam antibiotics is a serious problem worldwide. This resistance has emerged due to two main mechanisms: production of β-lactamases that hydrolyses β-lactam antibiotics and other is th...
PHARMACOGNOSTICAL, PHYTOCHEMICAL SCREENING AND STANDARDIZATION OF NELUMBO NUCIFERA (GAERTN): THE SACRED LOTUS
Objective: To perform the Phytochemical screening & standardization of Nelumbo nucifera Gaertn.Methods: The present study provides pharmacognostic, physicochemical and phytochemicals details of Parts of Nelumbo nucif...