DETERMINATION OF FLURBIPROFEN IN PHARMACEUTICAL PREPARATIONS BY FIRST-ORDER DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 2
Abstract
Flurbiprofen is a new non-steroidal anti-inflammatory agent, one of the propionic acid groups, which has significant anti-inflammatory, analgesic, and antipyretic properties. Clinically, it is used for the treatment of rheumatoid arthritis, degenerative joint disease, osteoarthritis, ankylosing spondylitis, acute musculoskeletal disorders, low back pain, and allied conditions. In this study, the first-order derivative spectrophotometry method was developed for the determination of flurbiprofen in pharmaceutical preparations. In the first derivative spectrophotometry, absorbance values were measured at 213, 233 and 260 nm. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit of quantitation were studied according to the International Conference on Harmonization Guidelines. A calibration curve was linear between the concentration ranges of 1-14 μg ml-1. Within- and between-day precision values for flurbiprofen were less than 4.95%, and accuracy (relative error) was better than 3.67%. The mean recovery value of flurbiprofen was 100.9% for pharmaceutical preparations. The developed method was successfully applied to tablet formulations and the results were compared statistically with each other.
Authors and Affiliations
Bilal Yilmaz
Keywords
Related Articles
- EP ID EP427115
- DOI -
- Views 120
- Downloads 0
A COMPREHENSIVE REVIEW ON PLANT EXTRACT AS AN HERBAL INDICATOR IN TRITREMETRIC ANALYSIS
The synthetic indicators are used in acid base titration for determination of end point. A part of its application, the synthetic indicators has several limitations such toxic in nature, costly, corrosive and etc. Thus,...
DIABETES AND ANTIDIABETIC HERBAL FORMULATIONS: AN ALTERNATIVE TO ALLOPATHY
The present study was based on diabetes, its cure & herbal products available in the market. Diabetes mellitus is the most common endocrine disorder, affecting 16 million individuals in the United States and 200 million...
PROTECTION OF HIPPOCAMPAL AND ISLET BETA CELLS IN VITRO BY EMODIN FROM LEAVES OF RUMEX CONFERTUS
The natural anthracene derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known as an anticancer agent. In the present work it was isolated for the first time from the ethanol extract of Rumex confertus leaves...
SYNTHESIS AND BIOLOGICAL EVALUATION OF CYCLOPROPANE DERIVATIVE OF COMBRETASTATIN CA-4-PHOSPHATE
Combretastatin A-4 (CA-4) is an anti-mitotic agent that is gaining rapid recognition amon cancer biologists and clinicians as one of the newer vascular disrupting agents, (VDAs) for cancer therapy. CA-4 belongs to a grou...
ARBUSCULAR MYCORRHIZAL FUNGAL DIVERSITY AND ROOT COLONIZATION OF SOME MEDICINAL PLANTS RHIZOSPHERE SOIL OF VRIDDHACHALAM, TAMIL NADU.
The present study was to analyze the occurrence of mycorrhizal diversity in 20 medicinal plants of Vriddhachalam, Cuddalore District, Tamil Nadu and to explore for structures correlated to the possible functional positio...