DETERMINATION OF FLURBIPROFEN IN PHARMACEUTICAL PREPARATIONS BY FIRST-ORDER DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 2
Abstract
Flurbiprofen is a new non-steroidal anti-inflammatory agent, one of the propionic acid groups, which has significant anti-inflammatory, analgesic, and antipyretic properties. Clinically, it is used for the treatment of rheumatoid arthritis, degenerative joint disease, osteoarthritis, ankylosing spondylitis, acute musculoskeletal disorders, low back pain, and allied conditions. In this study, the first-order derivative spectrophotometry method was developed for the determination of flurbiprofen in pharmaceutical preparations. In the first derivative spectrophotometry, absorbance values were measured at 213, 233 and 260 nm. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit of quantitation were studied according to the International Conference on Harmonization Guidelines. A calibration curve was linear between the concentration ranges of 1-14 μg ml-1. Within- and between-day precision values for flurbiprofen were less than 4.95%, and accuracy (relative error) was better than 3.67%. The mean recovery value of flurbiprofen was 100.9% for pharmaceutical preparations. The developed method was successfully applied to tablet formulations and the results were compared statistically with each other.
Authors and Affiliations
Bilal Yilmaz
Keywords
Related Articles
- EP ID EP427115
- DOI -
- Views 109
- Downloads 0
COMPARATIVE PHARMACOGNOSTIC STUDY OF LEAVES OF ADHATAODA VASICA AND AILANTHUS EXCELSA
Adhataoda vasica and Ailanthus excelsa are distributed throughout tropical and subtropical parts of India. Their leaves are used as expectorant and bronchodilator. The present investigation deals with the comparative pha...
MORTALITY AND REPELLENT ACTIVITY OF CLERODENDRUM VISCOSUM VENT. (VERBENACEAE) AGAINST SITOPHILUS ORYZAE (COLEOPTERA: CURCULIONIDAE)
In continuation of our study we have screened out the root, leaf, and stem of C. viscosum against rice weevil, S. oryzae extracted into ethanol, ethyl acetate, and chloroform. A correlation was found between the insectic...
BIOSYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SILVER AND GOLD NANOPARTICLES USING AQUEOUS STEM EXTRACT OF ALHAGI MAURORUM
Green synthesis is a cheaper, clean, non toxic route for synthesis of large scale nanoparticles without the use of high energy, pressure, temperature and toxic chemicals. With the help of microbial enzyme and plant extra...
EVALUATION OF PRESERVATIVE EFFECTIVENESS IN ANTACID, COUGH SYRUP AND OPHTHALMIC SOLUTION BY MICROBIAL CHALLENGE TEST
Pharmaceutical preparations having high water content face the problem of microbial spoilage which affects consumer safety. Control on such problem is generally done by the addition of a specific preservative to these ph...
A PRELIMINARY PHARMACOGNOSTICAL REPORT ON THE LEAF OF DREGEA VOLUBILIS (L.F.) BENTH. EX HOOK. F.
Dregea volubilis (L.f.) Benth. Ex Hook. f. is a large twinning shrub belonging to the family Asclepiadaceae. The leaf is amphistomatic with tetracytic, anomocytic, paracytic stomata. The sides of leaf in surface are stra...