Determination of Pattern of Multiple Antibacterial Resistance In Clinical Bacterial Isolates of Wound Infections
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 11, Issue 2
Abstract
The effectiveness of drugs and chemotherapeutic agents used against bacteria has recently declined due to various mechanisms used by the bacteria to prevent their actions. This study aims at detecting the mechanism of multidrug resistance in bacteria isolated from wound infections in patients attending University of Uyo Teaching hospital. Swabs from infected wounds were collected using aseptic methods. Culture and examination was done using standard microbiological techniques. Sensitivity test was done using disk diffusion technique. Curing was done using acridine orange. Staphylococcus aureus was the predominant species with 43.3% followed by Pseudomonas aeruginosa with 31.67%, Escherichia coli 11.7%, Proteus sp. 8.3% and Klebsiella pneumoniae 5.0%. The overall multidrug resistance was 68.3%. The results of the study further reveal that 61.5% of Staph aureus were resistant to more than eight antibiotics with multiple antibiotic resistance (MAR) index ranging from 0.22-0.89. Other organisms also exhibited various levels of multiple antibiotic resistance indexes. This study shows that the prevalence of multidrug resistant organisms was high and majority of the organism isolated exhibited plasmid mediated resistance. This identification enhances the development of new approaches to overcome the problem of antibiotic resistance as this causes a huge challenge in the treatment of infections within the community where more people get infected each day.
Authors and Affiliations
A. N. Umo, S. S. Simeon, S. A. Adie, E. J. Mendie
Keywords
Related Articles
- EP ID EP328448
- DOI 10.9734/JAMPS/2016/29155
- Views 103
- Downloads 0
In utero Exposure to Oxcarbazepine Causes Congenital Anomalies in Albino Rat Fetuses
Aims: Oxcarbazepine (OXC) is a newer antiepileptic agent that has recently become increasingly used either as monotherapy or as an adjunct to other AEDs in adults, adolescents, and children with partial epilepsy. Our aim...
A Review on Barleria prionitis: Its Pharmacognosy, Phytochemicals and Traditional Use
Barleria prionitis, belonging to Acanthaceae family, is a small spiny shrub, normally familiar as “porcupine flower” with a number of vernacular names. It is an indigenous plant of South Asia and certain regions of Afric...
Evaluation of Nutritional, Antifungal Properties and Activities of Hydrolytic and Oxidative Enzymes of Coccinia cordifolia Leaves
Objective: This study demonstrated the significant changes of nutritional compositions, hydrolytic and oxidative enzymes of C. cordifolia leaves at different maturity stages. Methods: Biochemical screening revealed the p...
Preliminary Investigation of the Subchronic Hypolipidemic Actions of Hibiscus sabdariffa in Rats
Hibiscus sabdariffa is a popular medicinal plant that is claimed to have hypotensive and hypocholesterolemic actions in animals. The present preliminary study was conducted to assess the subchronic hypolipidemic actions...
Potential 5-Fluorouracil Encapsulated mPEG-Chitosan Nanogels for Controlling Drug Release
Aims: The objective of this study was to prepare and characterize poly (ethylene glycol) methyl ether (mPEG)-conjugated chitosan (CS) nanogels, mPEG-CS, at different molar ratios for 5-Fluorouracil (5-FU) delivery (5-FU-...