Abstract

The study was performed to check the chemical, antioxidant, antimicrobial, and protein binding qualities of the hydroethanolic extract of Celastrus paniculatus (CP). Hydroethanolic extract of CP exhibited low antibacterial and antifungal activities. Excellent antioxidant activities (60–80%) were noticed for various antioxidant assays, namely, 2,2-diphenyl-1-picrylhydrazyl, metal chelating, ferric reducing ability of plasma, superoxide radical, and nitric oxide. Total phenolic content (TPC) and total flavonoid content (TFC) of the extract were 1.38 ± 0.15 mg/g (expressed in equivalents to gallic acid) and 8.91 ± 0.21 mg (expressed in equivalents quercetin), respectively. Moreover, at P ≤ 0.05, the significant linear correlation was noticed between the TFC/TPC and antioxidant activities favored which highlights the medicinal property of CP. Protein binding assay was performed, and an observed binding constant (1.11 ± 0.92 × 10−5/µM) was almost close to control (aspirin). Anti-inflammatory assay revealed the potent anti-inflammatory activity of the hydroalcoholic extract of CP. These significant findings of CP may provide compelling scientific evidence of its therapeutic potential.

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