Determination of required insulin dose to control blood sugar in patients with Gestational diabetes mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Nowadays rate of gestational diabetesmellitus (GDM) is increasing and it has numerous complications for both mother and newborn, so appropriate and timely treatment of GDM is very important. Insulin is the most common treatment to control blood sugar in GDM. Knowing the amount of insulin required during pregnancy could help doctors to better control blood sugar in women with GDM. This study aimed to determine the amount of insulin required to control blood sugar in patients with gestational diabetes.This is a retrospective study, carried out using medical records of 225 pregnant women aged 18 to 45 years diagnosed with GDM for the first time referred to Imam Khomeini Teaching Hospital in Ahvaz during 2016. Total daily insulin dose(TID) during pregnancy was recorded as units per kilogram, and the amount of insulin required in women with GDM was evaluated based on the characteristics of mother. The collected data were analyzed using SPSS version 23.00 (SPSS Inc., Chicago, IL, USA). This study showed that the amount of insulin required to control blood sugar by increasing gestational age significantly increases. So that the required insulin in gestational age less than 12 weeks: 0.52±0.09 units / kg / day, in 13 to 26 weeks: 0.64±0.05 units / kg / day, in 27 to 35 weeks: 0.73±0.08 units / kg / day, and more than 36 weeks to birth: 0.85±0.03 units / kg / day (P < 0.05). The results also showed that factors such as maternal age, Body mass index (BMI), parity, history of macrosomia birth, history of infertility and diabetes among close relatives mother do not affect in determining the 24-hours insulin dose (P > 0.05). The results of this study showed that gestational age is only factor in determining the amount of insulin required to control blood sugar in GDM. Because the studies in this field are very low,also many factors such as nutrition and stress during pregnancy effect on insulin requirements, so definitive decision about prescribed amount of insulin required to control blood glucose in GDM, need to do more studies in a controlled manner in the future. Keywords:Insulin requirements, pregnancy, gestational diabetes mellitus
Authors and Affiliations
Seyed Bahman Ghaderian, Masoud Haghighizadeh, Sholeh Saeb
Keywords
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