Developement Of Validated UV Spectrophotometric Method For Estimation of Sumatriptan Succinate In Bulk and Pharmaceutical Dosage Forms
Journal Title: Journal of Medical Science And clinical Research - Year 2013, Vol 1, Issue 2
Abstract
The present research work discussed the development of a UV spectrometric method for validation of Sumatriptan Succinate. It is simple, fast, accurate and cost efficient and reproducible spectrophotometric method, developed for the estimation of Sumatriptan Succinate as a pure API. The wavelength (max) was found to be 229 nm by using acetonitrile as a solvent for the Sumatriptan Succinate. The linearity for this drug at the selected wavelength lies between 2-20 μg/ml. Beer's law was obeyed in this concentration range with correlation coefficient of 0.999. The accuracy and precision of the method were determined and validated according to ICH guidelines. The method has good reproducibility with % RSD less than one. Thus proposed method can successfully applied for Sumatriptan Succinate in routine analysis work.
Authors and Affiliations
Siddharth M. Patil
Keywords
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