DEVELOPMENT AND CHARACTERIZATION OF PREDNISOLONE LIPOSOMAL GEL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 2
Abstract
The present objective for the study was to prepare prednisolone liposomal gel intended for topical application. Various liposome formulations were prepared using Vortexing Sonication technique using vacuum rotator evaporator by varying the lipid phase composition (lecithin/cholesterol). Liposome formulations were characterized for drug content, entrapment efficiency, surface morphology, surface charge, and stability studies. Topical liposomal gels were prepared by incorporation of liposome dispersion into structured vehicle carbopol (2 %). Alternatively, hydrogels containing prednisolone were prepared and their drug release properties were investigated. The percentage entrapment of drug was increased with increase in phospholipid composition in the range of 85-98 %. Liposomal gel showed prolonged release of prednisolone than the hydrogels. Results of all the studies suggested that Prednisolone liposomal gel formulation was therapeutically effective drug delivery system for treatment of Rheumatoid Arthritis.
Authors and Affiliations
Fatima Tatheer, Raza Mazahir, Anshul Shukla
Keywords
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- EP ID EP127236
- DOI 10.7897/2230-8407.06230
- Views 96
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