DEVELOPMENT AND EVALUATION OF KETOROLAC TROMETHAMINE MUCOADHESIVE BUCCAL TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: The aim of the present study was to develop and evaluate buccal mucoadhesive tablets of ketorolac tromethamine.Methods: The tablets were prepared by direct compression using bioadhesive polymers such as carbobpl 934 with hydroxylpropyl methylcellulose K4M and sodium carboxymethyl cellulose. The prepared tablets were characterized by different parameters such as weight uniformity, content uniformity, hardness, swelling index, in vitro drug release studies, ex- vivo residence time and ex- vivo permeation study.Results: F7 formulation containing Carbopol 934 and SCMC (at the ratio 1:3, respectively) showed good swelling, a convenient residence time as well as the highest amount of drug released within 6 hrs. Stability studies in natural saliva for 6 hrs, indicated that optimized F7 formulation has good stability in human saliva. In addition to the good correlation obtained between in vitro drug release and ex-vivo drug permeation study. Conclusion: The buccal mucoadhesive tablet of ketorolac could be an alternative route to reduce the pronounced gastrointestinal irritations, reduce dosing frequency to improve patient complains.
Authors and Affiliations
Marwa Shukr, Amal Abdel Rahim
Keywords
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