Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 4
Abstract
Pulsatile release profile is characterized by a lag time followed by rapid and complete drug release. Pulsatile drug delivery systems are classified into time-controlled and site-specific delivery systems. The lag time is taken as the time of less than 10% drug release. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps i.e. firstly core tablet was prepared containing Nifidipine; secondly core tablet was coated with polymer blend of ethyl cellulose (water insoluble polymer) and Eudragit L 100 (Enteric polymer). From the study it was concluded that the formulation having a coating level of 50% w/w of core and weight ratio of ethyl cellulose to Eudragit L 100 (20%) showed lesser release profile as compared to other formulation i.e. 52.83% in 12hrs. As we increase the weight ratio of ethyl cellulose to Eudragit L 100 better entrapment of drug leading to controlled release of drug.
Authors and Affiliations
Renu Dinkar| Department of Pharmacy,GIS Institute of Professional Studies, Dehradun. (Uttarakhand), India, Govind Mohan| Department of Pharmacy,NIMS University, Jaipur. (Rajasthan), India, Kumud Upadhyaya| Department of Pharmaceutical Sciences, Kumaun Univesity, Nainital. (Uttarakhand), India
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