DEVELOPMENT AND EVALUATION OF PIROXICAM LOADED BIOPOLYMER BASED TRANSDERMAL FILM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 11
Abstract
The aim of the present study was to formulate biopolymer based transdermal film loaded with Piroxicam (PX). Transdermal films were prepared by using sodium locust bean gum (LBG) and Sodium alginate (SA) as biopolymers by varying the blend ratios by solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, content uniformity; transdermal permeation of PX through rat abdominal skin was determined by Franz diffusion cell. In vitro skin permeation profile of optimized formulation was compared with that of PX conventional gel. Carrageen induced rat paw edema model was used to investigate the in vivo performances. Menthol (3%) and glycerin (3%) are used as permeation enhancer and plasticizer, respectively. PX was found to be compatible and stable with the prepared formulation as confirmed by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetric (DSC), studies. In-vitro release studies revels effectiveness after 24 h when compared with the conventional gel. The film does not show any signs of edema, erythema or ulceration. From the in-vitro skin permeation and anti inflammatory activity data it can be concluded that the developed optimized formulation (F3) has good potential to achieve the transdermal drug delivery of PX for effective therapy.
Authors and Affiliations
Parthasarathi Kulkarni , Mudit Dixit , Lavanya D. , L. Naga Krishna, Prudhvi R.
Keywords
Related Articles
- EP ID EP150706
- DOI -
- Views 111
- Downloads 0
CHRONOPHARMACOLOGY: A TOOL FOR THERAPY OF DISEASES
Chronopharmacology is useful to solve problems of drug optimization, i.e. to enhance the desired efficiency or to reduce its undesired effects. In the human organism (among other animal species) the metabolic fate of a p...
ROLE OF VARIOUS OPIOID RECEPTORS IN OPIOID DEPENDENCE AND WITHDRAWAL SYNDROME
Although dependence liability of opioids is widely recognized, the relative involvement of different opioid receptors mediating physical dependence is not completely known. The present study was aimed to explore the role...
ANTI-ALZHEIMER POTENTIAL OF ORANGE JUICE
Orange (Citrus sinensis) is well known for its nutritional and medicinal properties throughout the world. This study was undertaken to test the effect of orange juice on the memory of mice. A total of 228 mice divided in...
PHYTOCHEMICAL AND ANTI-DIARRHOEAL PROPERTIES OF METHANOL ROOT EXTRACT OF GUIERA SENEGALENSIS J.F. GMEL
The study investigated the anti-diarrhoeal properties and phytochemical constituents of the methanol root extract of Guiera senegalensis. The phytochemical components of the extract were evaluated. White Wister strain al...
ADJUVANT USE OF SILYMARIN IN PATIENTS WITH HYPERTENSION AND MICROALBUMINURIA
Microalbuminuria is an important micro-vascular complication of hypertension. It has been reported that polyphenolic compounds provide protection against the risk of cardiovascular diseases. The present study was designe...