DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 1
Abstract
The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability. In–vitro release study was performed for 10 hrs. Selected formulation was subjected to stability testing at different temperatures.
Authors and Affiliations
Saifullahi Umar, Moh Kingsley Onyekachi
Keywords
Related Articles
- EP ID EP36377
- DOI https://doi.org/10.22270/ujpr.v2i1.R4
- Views 341
- Downloads 0
PRODUCT RECALL: A COMMENTARY ON RISING INCIDENCES
There has been an increasing trend in the number of prescribed and over-the-counter drug recall over the last few years. The recall is usually due to company's discovery, customer's complaint or Food and Drug Administra...
THE IMPACT OF STRATEGIC FACTORS OF WASTE MANAGEMENT ON ENVIRONMENTAL PROTECTION IN KAZEROON CITY IN 2017
Today, environment protection is one of main pillars of observing human right, so that protection and maintenance of environment is one of main duties of present and future. After investigating and identifying environmen...
THE ASSOCIATION OF EPSTEIN-BARR VIRUS ANTIBODIES WITH RHEUMATOID ARTHRITIS AMONG YEMENI PATIENTS IN SANA’A CITY
Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with progressive disability, systemic complications and early death. Etiology of RA is unknown. It is assumed that environmental factors initia...
THE RELATION BETWEEN GENERAL HEALTH AND ORGANIZATIONAL PERFORMANCE IN PERSONNEL OF SHIRAZ CITY EMERGENCY IN 2017
Health is the fundamental right of every human and a social goal and all governments and organizations are bound to supply individuals' health and organizational performance is considered one of the most important struc...
DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM
The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic...