DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 5
Abstract
Objective:To optimize and develop Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensiveMetoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated.. Result: Within 5 minutes in acidic medium , 7% Superdisintigant (Crosspovidone), 7% Surfectant (Polysorbate-80), 15% Alkalizing agents(Sodium bicarbonate), 5% HPC (Binding agent) averagely produce 68.56%drug release. Within 20 hours in acidic medium , 30% Alkalizing agents(Sodium bicarbonate) , 50% Soluablepolymer (HPMC K) ,40% Polymer (Udragid RSPO, 35% HPC Polymer(NaCMC), 30% Polymer (Sodiumalginate) ,25% Polymer (HPC) , 20% Polymer, Udragid RS), 5% HPC Polymer (PVPK) produce averagely100.06% drug release. Conclusion:The optimized formulation 400 mg tablet weight of OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) produce better result and identified as better formulation for further studies.
Authors and Affiliations
Sreedhar Ranjan Das , Bibhuti Bhusan Panigrahi And Manoj Kumar Pani.
Keywords
Related Articles
- EP ID EP601086
- DOI 10.21474/IJAR01/9105
- Views 92
- Downloads 0
USE OF MUCODERM? COLLAGEN MATRIX IN PERI-IMPLANT AESTHETIC DEFECT CORRECTION.
Introduction: Soft tissue defects around osseointegrated implants have stimulated the development of techniques aimed at reducing these defects, especially when located in areas of the premaxilla. Case Report: A 40-year-...
SPLENOGONADAL FUSION MIMICKING A MALIGNANT TESTICULAR MASSE: A RARE CASE REPORT.
Splenogonadal fusion is an extremely rare congenital anomaly that results from abnormal connection between the ectopic splenic tissue and the gonade during embryonic development, frequently associated with cryptorchidism...
THE INFLUENCES OF DEMENSIA ON THE FULFILLMENT OF DAILY LIVING ACTIVITY (ADL) IN ELDERLY PEOPLE
Objective: This study aimed at analyzing and then determining whether there was an effect of dementia on the fulfillment of Activity of Dayling Living (ADL) over some social institutions in 2017. This study used a non-ex...
PREDICTORS FOR SUCCESSFUL LABOUR INDUCTION WITH PGE2 IN PRIMIGRAVIDA.
Objective: To identify independent predictors of successful labor inductionWith PGE2 in Primigravidas. Methods: This retrospective study was, conducted at KAASH Hospital, TAIF, KSA. The Medical and Nursing Records of 401...
IMPROVED PERFORMANCE FOR THE HUMAN RESOURCES APPARATUS THROUGH TRAINING AND PROMOTIONS PUBLICATIONS ON PUBLIC SERVICE IN DEPARTMENT OF INVESTMENT AND INTEGRATED SERVICES OF THE MALANG REGENCY.
This research is an explanative explanation of causality that aims to analyze the influence of education and training variables (Diklat) as well as promotion of position on the performance of employees that have implicat...