Development And Optimization of Boswellia Serrata Self-Micro Emulsifying Formulation: An Ameliorative Effort Towards The Herbal Formulation
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 1
Abstract
Abstract: Development of self-micro emulsifying drug delivery system (SMEDDS) of herbal extracts is challenging task per se, as the herbal extracts contains many active and non-active constituents with various physicochemical properties. Present work focuses on development and evaluation of self-micro emulsifying formulation of Boswellia Serrata Extracts (BSE). An optimized formulation of BSE-SMEDDS composed of the equal fraction of Capmul-MCM®, Acrysol EL135® and Acconon MC8® was developed by employing the 33 Full Factorial experimental design.The optimized formulation having capability to self-micro emulsification within less than one minute and droplet size of 189.3 nm (0.432 PDI) was evaluated for In-vitro drug release and ex-vivo diffusion for its comparison with the marketed formulation of the Boswellia Serrata Extract.
Authors and Affiliations
Krunal Detholia, Dashrath Patel, Swayamprakash Patel
Keywords
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