DEVELOPMENT AND OPTIMIZATION OF HYDRODYNAMICALLY BALANCED GASTRORETENTIVE FLOATING TABLETS OF ATENOLOL
Journal Title: Innoriginal: International Journal Of Sciences - Year 2015, Vol 2, Issue 1
Abstract
The present work was aimed to develop a floating drug delivery system of Atenolol based on novel approaches and to investigate there In vitro drug release and buoyancy performance. The interaction between the excipcents and Atenolol was also studied through FTIR spectroscopy. Tablets were then prepared by direct compression technique using different combinations of polymers. All the formulations were analyzed for pre-compression and post-compression parameters. The pre-compression and post-compression parameters of all the formulations were within the required and acceptable limit. From the in-vitro buoyancy studies the floating lag time and duration of buoyancy were found to be satisfied. In vitro drug release studies revealed that F3 shows much higher dissolution rate. In vitro release data were fitted to various kinetic models. The mechanism of drug release from tablets was found to be non-Fikian, anomalous transport. Results from various evaluations suggested that matrix type Atenolol floating tablets could be used as hydrodynamically balanced gastroretentive floating drug delivery devices.
Authors and Affiliations
Arun Raj. R
Keywords
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