Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 3
Abstract
Transdermal patches of Losartan with hydrophilic and hydrophobic polymers containing the drug reservoir were prepared by solvent evaporation method. In this experiment, the membranes of ethylcellose and eudragit RS 100 were used to achieve controlled release of the drug. The prepared patches showed satisfactory physiochemical characteristics of weight variation, thickness, folding endurances, moisture absorption and drug content were uniform in all patches. In-vitro permeation studies were done by using Franz diffusion cell having cellophane membrane. The effect of non- ionic surfactant like tween 80 and span 80 on drug permeation were studied. Based on the kinetic studies, the patch containing both HPMC and Eudragit RS100 showed satisfactory drug release patterns.
Authors and Affiliations
V. Vijaya , M. H. Sumanth , L. Suman , T. Vinay , D. Srinivasrao , K. Jayaraj Kumar
Keywords
Related Articles
- EP ID EP107947
- DOI -
- Views 114
- Downloads 0
HPTLC Determination of Amoxicillin Trihydrate and Bromhexine Hydrochloride in Oral Solid Dosage Forms
A simple, accurate, precise and rapid high-performance thin-layer chromatographic method for determination of Amoxicillin Trihydrate and Bromhexine Hydrochloride in Bulk and combined Pharmaceutical Dosage Form was develo...
REVIEW ON: PULSATILE DRUG DELIVERY SYSTEMS
Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. A pulsatile drug release, where the drug is release...
[b][/b]Evaluation of antimicrobial activity and phytochemical screening of Gelidium acerosa
Seaweeds has become a recognized potential natural product in pharmaceutical industries. The Gelidium acerosa contain large amount of valuable phytochemicals like sapononins, flavinoids and alkaloids etc...
Anti-Hyperglycemic And Antidyslipidemic Potential Of Azadirachta indica Leaf Extract In STZ- Induced Diabetes Mellitus
Azadirachta indica , an Indian medicinal plant, has been studied for its role in diabetes and its effect on lipid profile. This study was conducted to elucidate whether treatment of Azadirachta indica leaf extract afte...
Formulation and Evaluation of Levofloxacin Using Different Types and Concentrations of Superdisintegrants
Levofloxacin is a fluoroquinolone anti bacterial drug effective in the treatment of bacterial conjunctivitis. Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. The objective of th...