Development and Validation of RP-HPLC assay method for the Estimation of Dronedarone in bulk and Pharmaceutical Preparations
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 1
Abstract
A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of Dronedarone in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on an ODS C18 column (250 x4.6 mm x 5µm length), using a composition of water (0.2% Tri Ethyl Amine):Methanol (20:80v/v) pH adjusted to 3 with Ortho Phosphoric acid as the mobile phase at a Flow Rate of 1 mL/min and the detection was done at 283 nm. The retention time of the drug was 4.707 min. The method produced linear responses in the concentration range of 20-120µg/mL of Dronedarone. The method was found to be reproducible for analysis of the drug in Tablet preparations. Keywords: Dronedarone, RP-HPLC, tablets dosage forms, validation.
Authors and Affiliations
Sk Mastanamma, S. Krishna Chaitanya, P. Saidulu, K. Sravani
Keywords
Related Articles
- EP ID EP376881
- DOI -
- Views 100
- Downloads 0
Medicinal plants affected reproductive systems (part 2) - plant based review
In our previous paper, we reviewed the reproductive effects of many medicinal plants included Achillea santolina, Ailanthus altissima, Alhagi maurorum, Allium cepa, Althaea rosea, Ammannia baccifera, Anthemis nobelis,...
Event Monitoring in Patients Prescribed with Anti-tubercular Therapy
Tuberculosis is a chronic, granulomatous infectious disease caused by Mycobacterium tuberculosis. Multi-drug resistance is a chronic problem associated with treatment of tuberculosis where a substantial proportion of tub...
Assessment of Implementation of Good Manufacturing Practices (GMPs) at Pharmaceutical Firms in Khartoum State-Sudan
Good Manufacturing Practices (GMPs) ,the central part of quality system, is the consistent production of safe and effective product and ensuring that these activities are sustainable. It aims primarily at preventing mist...
Synthesis, Characterization and Pharmacological Screening of Substituted Sulphonamide Derivatives
Sulphonamides are an important class of heterocyclic compounds which possess wide spectrum of biological properties.The present work deals with the synthesis of some novel Sulphonamide derivatives using acetanilide, chlo...
Community Pharmacy in Warri, Nigeria – A Survey of Practice Details
Activities of community pharmacists could have a profound impact on the health of the public. Knowledge of routine daily activities of community pharmacists could can be harnessed to ensure optimum and safer se...