Development and Validation of RP-HPLC for Estimation of Neratinib in Bulk and Tablet Dosage Form
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2019, Vol 11, Issue 2
Abstract
An accurate RP-HPLC method developed for the estimation of Neratinib in bulk and tablet dosage form. The method is and validated for parameters linearity, accuracy, suitability, specificity, precession, LOD, LOQ and robustness. An Altima column (150 mm × 4.6 mm × 5µ) used for chromatographic separation within a runtime of 6 min. The mobile phase buffer (monopotassium phosphate) and acetonitrile (60:40 v/v) with 0.1% formic acid is used. The flow rate maintained at 1.0 ml/min with the effluents monitored at 215 nm. The Neratinib analyzed at retention time of 4.001. The concentration linear over 30-180µg/ml with regression equation y = 6065.6x + 795.43 and regression co-efficient 0.999.
Authors and Affiliations
M Lakshmi Kanth, B Raj Kamal
Keywords
Related Articles
- EP ID EP499330
- DOI 10.25004/IJPSDR.2019.110202
- Views 74
- Downloads 0
ANTI-FLATULENT STUDIES OF TRADITIONAL MEDICINAL PLANT VITEX NEGUNDO LINN. IN RATS
Vitex negundo is a shrub from Verbenaceae family and is traditionally used in treatment of various disease and disorders. Oil prepared with the juice of leaves of Vitex-negundo is reported to have very useful medicinal p...
DEVELOPMENT AND VALIDATION OF CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC TECHNIQUE FOR SIMULTANEOUS ESTIMATION OF CINITAPRIDE AND PANTOPRAZOLE FROM BULK AND COMBINED DOSAGE FORM
This paper describes two sensitive, accurate and precise chemometric spectrophotometric methods for the simultaneous determination of Cinitapride hydrogen tartarate (CNT) and Pantoprazole sodium (PANTO) in bulk powder an...
ANTIANXIETY ACTIVITY OF FRACTIONS AND ISOLATED COMPOUNDS OF VERBENA OFFICINALIS AERIAL PARTS
Verbena officinalis L. (Vervain; family-Verbenaceae) has long been used in the treatment of mental disorders, but not validated systemically for traditional claims. The ethyl acetate fraction (rich in flavonoids) of V. o...
PROGRESS AND PROSPECTS IN THERAPEUTICS AGAINST HIV INFECTION
Tremendous advances have occurred in recent decades in the development of safe and effective medications for the treatment of viral diseases. Currently there are more than 20 HIV drugs approved for use in humans. Combine...
CHROMATOGRAPHIC FINGERPRINT ANALYSIS OF IXORA COCCINEA METHANOLIC FLOWER EXTRACT
Ixora coccinea (R.) belonging to the Rubiaceae family is an ornamental plant claimed for the management of oral cancer and one of ingredients in curing different ailments. The present investigation was carried out to det...