Abstract

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Vortioxetine in its pure form as well as in tablet dosage form. Chromatography was carried out on ODS C18 4.6 x 250 mm, 5µm column using Acetonitrile And Methonal 70 30 as the mobile phase at a flow rate of 1.0 mL min, the detection was carried out at 274nm. The retention time of the Vortioxetine was 2.922 ±0.02min. The method produce linear responses in the concentration range of 20 µg ml of Vortioxetine. The method precision for the determination of assay was below 2.0 RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Rathod K. G | Bargaje G. S | Rathod G. R | Deshpande O. V "Development and Validation of RP-HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd28040.pdf Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/28040/development-and-validation-of-rp-hplc-method-for-estimation-of-vortioxetine-in-bulk-and-pharmaceutical-dosage-form/rathod-k-g

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