DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF PARACETAMOL AND DICLOFENAC SODIUM IN BULK AND TABLET DOSAGE FORM
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 1
Abstract
Two simple, specific, sensitive, rapid, precise, accurate and economical UV Spectrophotometric methods viz. simultaneous equation method and Q-Absorbance ratio method have been developed and validated for the routine estimation of Paracetamol and Diclofenac Sodium in bulk and tablet dosage form. The absorption maxima of drugs were found to be at 247 nm for Paracetamol and 276 nm for Diclofenac sodium and iso-absorptive point at 265 nm in distilled water and these wavelengths were selected for the analysis. Paracetamol and Diclofenac sodium obeyed Beer- Lambert’s law in the concentration range of 6-30 μg/ml at 247 nm and 276 nm respectively. Simultaneous equation method and Q-analysis method have been used in the estimation of both the drugs. Both the methods show good accuracy and precision which was validated statistically. These methods require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
Authors and Affiliations
Derkar Ganesh K , Chimkode R. M , KatoreGaurav , KambleYogesh , JadhavRohini, , Gurav Anita , Kamble Ashwini
Keywords
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