Development of antiasthmatic polyherbal formulation (triratna) as an alternative to synthetic steroidal formulation
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 5
Abstract
In this study, methanolic leaves extract of Physalis angulata Linn (Solanaceae) (PAL), Adhatodavasaka Linn (Acanthaceae) (AVL) and Solanum nigrum Linn (Solanaceae) (SNL) and formulation (Triratna) of these three extracts were studied for antihistaminic properties by using isolated animal smooth muscle models to find out an alternative to synthetic steroidal formulation, where PAL possesses inhibitory efficacy by 99.58% (1Bg), 101.66% (2Bg), 102.08% (4Bg) in Guinea Pig ileum preparation (GPIP) against 1μg histamine; 100% (1Bg), 133% (2Bg), 126% (4Bg) in Guinea Pig tracheal chain preparation (GPTCP)against 1μg histamine and 50% (1Bg), 75% (2Bg), 100% (4Bg)in fundus strip preparation (FSP) against 1μg 5HT. AVL possesses inhibitory efficacy by 96.66%(1Bg), 97.5% (2Bg), 101.25%(4Bg) in GPIP against 1μg histamine, 46.66% (1Bg), 60% (2Bg),120% (4Bg) in GPTCP against 1μg histamine and 75% (1Bg), 100% (2Bg), 102.5% (4Bg) in FSP against 1μg 5HT. SNL posses inhibitory efficacy by 98.33% (1Bg), 101.25% (2Bg), 102.08% (4Bg) in GPIP against 1μg histamine, 73.33% (1Bg), 100% (2Bg), 120% (4Bg) in GPTCP against 1μghistamine and 25% (1Bg), 50% (2Bg), 75% (4Bg) in FSP against 1μg 5HT. While formulation possesses synergetic effect viz.125% (1Bg), 141% (2Bg) and 153% (4Bg) of inhibition against (1Bg) histamine in GPIP and 73%(1Bg), 105% (2Bg) and 115% (4Bg) of inhibition against 1 Bg histamine in GPTCP. Acute toxicity study of formulation also performed to measure the safety prospective of the formulation that confirmed safety measure of the formulation. Triratna could be novel anti antiasthmatic formulation for next generation.
Authors and Affiliations
Chhaya Rathore Sahu, K. R. Dutt, R. K. Goel, Rajesh Garg, Shobharam Sahu, Lokesh Deb
Keywords
Related Articles
- EP ID EP33249
- DOI -
- Views 250
- Downloads 0
Efficacy and tolerability of corticosteroids in pediatric cancer chemotherapy patients
Efficacy and tolerability in the treatment of pediatric cancer was studied in the present investigation. Prednisone, Hydrocortisone, Dexamethasone, Prednisolone and Methyl prednisolone were used in the treatment. The p...
EFFECTS OF PERMEABILITY CHARACTERISTICS OF DIFFERENT POLYMETHACRYLATES ON THE PHARMACEUTICAL CHARACTERISTICS OF DILTIAZEM HCL-LOADED MICROSPHERES
Microspheres containing Diltiazem hydrochloride (DTZ Hcl) were prepared with various Polymethacrylates, with different permeability characteristics (Eudragit RSPO and Eudragit RLPO) and also with mixtures of these poly...
Evaluation of nephroprotective activity ethanolic extract of stem bark extract of Tephrosia purpurea
Objective: To evaluate the nephroprotective activity of Ethanolic extract of Tephrosia purpurea (T.purpurea) (Fabaceae) in Gentamycin and Cisplatin-induced acute renal failure in rats. Materials and Methods: Tephrosia...
Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats
The aim of the present study is to evaluate the antiulcer activity of Clitorea ternatea leaves (Linn) in experimentally induced animal models. In this study the leaves of Clitorea ternatea was extracted with petroleum...
Formulation and evaluation of metoclopramide hydrochloride mouth dissolving tablet
Metoclopromide hydrochloride mouth dissolving tablets preparing were evaluated for pre compression and post compression parameters. The results obtained for angle of repose of the powdered blends was less than 30°, the...