Development of CelecoxibTransfersomal gel for the Treatment of Rheumatoid Arthritis
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for various parameters including vesicle shape, size and size distribution, surface morphology, entrapment efficiency, in-vitro and ex-vivo drug release and in-vivo anti-inflammatory activity. Vesicles were also evaluated for skin irritation study and permeation studies.Results of all the studies suggested that CelecoxibTransfersomal gel formulation was therapeutically effective drug delivery system for treatment of Rheumatoid Arthritis.
Authors and Affiliations
Preeti| Nanomedicine Research Center, Department of Pharmaceutics, Rajendra Institute of Technology and Sciences, Institute of Pharmacy, Sirsa, Haryana, India, Murugesan Senthil Kumar| Himachal Institute of Pharmacy, Paonta sahib, HP. 173025, India
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