Development of novel gastroretentive mucoadhesive pulsetile tablets for zileuton
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 3
Abstract
In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers (Ethyl cellulose, EudragitL-100, EudragitS-100) by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests.. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of nocturnal asthma. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. In vitro release of Zileuton core tablet formulations F1 (Drug, SSG, Talc, Magnesium stearate, MCC pH 102) showed faster drug release after 15 mins. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric coated formulations C1, C3, showed maximum drug release after 4 hour. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C3, C6 and C9 with 95.5%, 94.76% and 97.48 % respectively
Authors and Affiliations
Vancha Harish
Keywords
Related Articles
- EP ID EP408550
- DOI -
- Views 101
- Downloads 0
Second hand smoke exposure associated with risk of invasive meningococcal disease: Commentary reviews based on epidemiological evidence
Summary Overview of systematic reviews of observational epidemiological evidence suggests that passive smoking is significantly associated with an increasing risk of many diseases or health problems, especially meningit...
A questionnaire based survey on antibiotic usage and resistance among second professional medical students in a tertiary care centre
BACKGROUND Antibiotics are among the most commonly prescribed medications which serve a very useful therapeutic purpose in eradicating pathogens; however they are very often misused. Health science students who are futu...
Satisfaction level of outpatients in multispeciality hospitals
In the midst of, mounting number of multi specialty hospitals, there are certain benefits that the outpatient avail apart from primary health centers and clinics including Medical practitioner and specialist fees, Routin...
A prospective study on the efficacy of two drug combination chemotherapy in patients with malignant gonadal germ cell TUMORS
Malignant gonadal germ cell tumors are the rare malignant tumors which occurs in young individuals at the peak of their reproductive life between 18- 45yrs. Germ cell tumors are sensitive to chemotherapy as well as radio...
Phenobarbitone induced steven johnson syndrome (SJS) Case report
Introduction Adverse drug reactions (ADRs) are one of the leading causes of death in hospitalized patients. ADR is a response to a drug which is noxious, unintended and occurs at doses normally used in human for prophyl...