Development of qulity control methods for cream based on clotrimazole and urea
Journal Title: Фармацевтичний журнал - Year 2015, Vol 2, Issue 2
Abstract
Foot mycosis is varied in the population between 5% up to 20% and in some causes could reach 50% within the patients with chronic disease. There are some difficulties with treatments of mycosis with conducting by hyperkeratosis. Hence, development of medicines with target action with consideration of etiology of skin disease is actual. There is on going development of soft medicines base on clotrimazole and urea for fungous skin disease treatment which conducting by hyperkeratosis is taken place on pharmaceutical technology and biopharmacy department of Shupyk National Medical Academy of Post-graduate Education. Development of quality control methods of soft medicine based on clotrimazole and urea is the main target of current work. The object of study is cream base on oil/water emulsion type with consistent of clotrimazole (1%) an urea (5%). Quality control of medicine (description, homogeneity, pH) was conducted in compliance with State Pharmacopeia of Ukraine. Identification and quantity of clotrimazole was conducted by HELC (high-efficiency liquid chromatography); urea was detected by coloration and titration analysis accordingly. Estimation of general appearance, organoleptic qualities and homogeneity of cream samples was homogeneity, good consistence, white color, odorless. Value of pH is 6,6–6,7. It was found that quantity of active pharmaceutical ingredients in the medicine is within normal ranges, particular concentrations. Total number of aerobic microbial count (TAMC) is not more than 50 CFU/g; Total number of combined yeasts/moulds count (TYMC) is not more than 10 CFU/g; Staphylococcus aureus and Pseudomonas aeruginosa in 1g have not been found were found by microbiological study which is in compliance with State Pharmacopeia of Ukraine. Specified characteristics for cream based on clotrimazole and urea was found by complex study.
Authors and Affiliations
Aram Dullah, I. O. Vlasenko, G. P. Petynin, L. L. Davtyan, С. V. Birukova
Keywords
Related Articles
- EP ID EP583335
- DOI -
- Views 58
- Downloads 0
Study of the acute toxicity of the praziquantel using different routs of administration
Patients with similar to acne dermatosis have more strongly pronounced clinical symptoms and significant increase of relapses rate in case of the demodicosis presence. Praziquantel is an antiparasitic substance with acti...
Anatomical structure of the leaves and flowers оf primrose (Primula veris L.)
Primula (Primula veris L., Primula officinalis Hill.) is a perennial herbaceous plant with a short rhizome and threadlike roots. The leaves are radical, oblong-ovate, wrinkled. The flowers are regular, bright yellow, loc...
Motivation of obtaining higher pharmaceutical education of students of the National Pharmaceutical University
Choice of profession is the main factor in the further life of man, his attitude to himself and the world. When choosing a profession, a person is guided by a number of motives. In modern society, the motives of high sc...
Historical genesis in establishment of pharmaceutical business in Ukraine in an diferens stages of its social-economic and political development. P a r t II. Study of the period 1930–1960
During the period of industrialization, which was carried out in the former USSR, where Ukraine was one of the integral part and as well as in wartime and postwar period Ukrainian pharmacy performed an important social f...
Study of stability of gel with essential oils for the treatment of diseases of upper respiratory tract
At this stage, the stability of the gel was studied to determine the shelf life of the developed medicine means both at room temperature and in a cool place. The goal of our research was to study the shelf life and stab...