Development of sandwiched osmotic tablet of Glipizide
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 8
Abstract
The Sandwiched Osmotic Tablet System (SOTS), which is composed of sandwiched osmotic tablet core surrounded by a cellulose acetate membrane with two orifices on both side surfaces has been successfully prepared with the purpose of delivering Glipizide. In this a core composed of polymeric push layer sandwiched between two drug layers with two delivery orifices. Influences of tablet formulation variables and membrane variables on Glipizide release of SOTS have been studied. NaCl was used as an osmogent and MCC used as a release retardant. Cellulose acetate was used as the semipermeable membrane and PEG 400 was used as pore forming agent. Optimization was done using 32 factorial design considering two independent variable at three levels. Optimized formulation exhibited zero order kinetics with a drug release of 98.10 % in 24 hrs. The optimized formulation was also found to stable upon stability studies. The ideal formulation (F6) was stable when it was stored at 40±2 0c/ 75±5% RH as per ICH Guidelines for 6 months. It can be concluded that release of Glipizide was significantly controlled from sandwiched osmotic drug delivery systems.
Authors and Affiliations
Khairnar, A. B. , Gondkar, S. B. , Saudagar, R. B.
Keywords
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