DEVELOPMENT OF THERMOSENSITIVE GEL OF FLUCONAZOLE FOR VAGINAL CANDIDIASIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Objective: The aim of the present study was to develop in-situ gelling formulations of Fluconazole (FCZ) using thermosensitive polymer for treatment of vaginal Candidiasis.Methods: In-situ gelling formulations of FCZ (1 % w/w) were prepared with different concentrations of Poloxamer 407 (P 407, 15-20% w/w) using the cold dispersion method. Similarly, Â formulations were also prepared by adding mucoadhesive polymers like hydroxyethyl cellulose, Polycarbophil, Carbopol 974 and Hydroxypropyl methylcellulose E 50 LV (0.4 % w/w) to the P 407 formulations. These formulations were evaluated for appearance, clarity, pH, gelling ability, gelling time, gelling temperature, viscosity (in sol and gel forms), spreading time, ex-vivo mucoadhesion, in-vitro dissolution, morphological characteristics by SEM and in-vitro antifungal efficacy against Candida albicance. In-vivo vaginal irritation of developed formulation was assessed in New Zealand female rabbits. Results: In-situ gelling formulation of FCZ, prepared using 18 % w/w P407 and 0.4 % hydroxyethyl cellulose, was optimized since this formulation was found to be clear, transparent, forming a quick and stable gel with shear thinning behaviour and excellent mucoadhesion. The developed formulation released 74.21% of FCZ after 8 h of dissolution in 5.2 pH citrate buffer. In-vitro antifungal activity against Candida albicance showed the stronger antifungal activity of formulation as compared to a marketed formulation. In-vivo vaginal irritation study in rabbits demonstrated no significant irritation after 10 d of exposure to the formulation. Conclusion: The study demonstrated that in-situ gelling formulation of FCZ prepared using thermosensitive polymer had improved activity against Candida albicance and would be efficacious for the treatment of vaginal Candidiasis.
Authors and Affiliations
Sanjeevani S. Deshkar, Arun T. Patil, Sushilkumar S. Poddar
Keywords
Related Articles
- EP ID EP577975
- DOI -
- Views 71
- Downloads 0
PREPARATION AND IN-VITRO EVALUATION OF DESLORATADINE FLOATING TABLETS
Objective: Desloratadine is histamine H1 – receptor antagonist used in treatment of allergic and rhinitis conditions. The tablets were prepared by direct compression technique,using polymers such as Carbopol 934P,Carbo...
A COMPARATIVE STUDY OF CHEMICAL COMPOSITION OF ACACIA SEYAL STEM, STEM WOOD AND STEM BARK DRY DISTILLATES USED BY SUDANESES WOMEN AS COSMETIC AND MEDICINE
Objective: The content and chemical composition of dry distillates of the stem, stem wood and stem bark of Acacia seyal were investigated. The distillates are fumigants of A. seyal locally known in Sudan as Dokhan and wi...
ANTIOXIDANT AND ANTIPROLIFERATIVE POTENTIALS OF MARINE ACTINOMYCETES
Objective: The aim of present studyis to isolate and characterize a novel actinomycetes strain from marine sediments collected at Kakinada coast. To evaluate antioxidant and antiproliferative activities of the crude meth...
DESIGN OF COX-2 INHIBITORS–AN IN-SILICO APPROACH
Objective: The aim of the present work was to design the novel series of chalcone derivatives of indane-1,3-dione for its inhibition towards COX-2.Methods: COX-2 inhibitors were designed on the binding ability of the com...
FREEZE DRIED INJECTABLE DRUG PRODUCT DEVELOPMENT: SELECTION OF NON FUNCTIONAL ADDITIVES
Article Retracted from Publication due to copyright violence