Dexmedetomidine versus Esmolol to attenuate the extubation response following surgeries under general anaesthesia - A comparative study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Extubation of trachea always brings about acute, transient, undesirable hemodynamic and airway response which is sometimes fatal in susceptible patients. To attenuate this undesirable extubation response Dexmedetomidine and esmolol have been used. In present study we have compared the efficiency of two drugs in attenuation of hemodynamic and airway response during tracheal extubation. Methods: A Prospective, randomized, double blinded controlled study was carried in our hospital, After obtaining ethical clearance and written informed consent from the patients, 100 patients aged 18-50 years of ASA 1 and ASA 2 were randomly allocated into 2 groups. Group D received 1mcg/kg of dexmetomidine over 10 mins prior to extubation. group E received 1.5mg/kg of esmolol 2mins prior to extubation. Results: significant attenuation of hemodynamic and airway reflexes observed ingroup D when compared to group E. Conclusion: When compared to Esmolol (1.5mg/kg), Dexmedetomidine(1mcg/kg) effectively suppresses cough and attenuates hemodynamic responses to tracheal extubation without causing clinically significant delayed emergence.
Authors and Affiliations
G Amarappa, Balaraju Thayappa C, Rajesh S B, Meghana Mishra, Sai Mahesh Kuntrapaka
Keywords
Related Articles
- EP ID EP589655
- DOI 10.26611/10151024
- Views 170
- Downloads 0
A comparative study of haemodynamic and electrolyte changes between 1.5% Glycine and distilled water as irrigation fluid for transurethral resection of prostate surgeries
This prospective comparative study was conducted to study and compare the perioperative haemodynamic and electrolyte changes when 1.5% Glycine and sterile distilled water is used as an irrigation fluid for transurethral...
Effect of spinal anaesthesia on perioperative hyperglycemia in diabetic patients undergoing lower limb orthopaedic surgeries
Background and Aims: Surgery evokes stress response resulting in increased secretion of counter-regulatory hormones (catecholamines, cortisol, glucagon, and growth hormone) and excessive release of inflammatory cytokines...
Evaluation of adding clonidine to lignocaine during bier’s block in upper limb surgeries
Background and aims: Bier’s block a.k.a Intravenous regional anaesthesia (IVRA) is used for short duration procedures for limb surgeries. IVRA provides reliable analgesia with good muscular relaxation of the extremity di...
Comparative study of intrathecal dexmedetomidine and intrathecal magnesium sulphate used as adjuvants with hyperbaric bupivacaine in lower abdominal and lower limb surgeries
Background: Subarachnoid block is the most commonly used regional anesthetic technique for lower abdominal and lower limb surgeries. Intrathecal adjuvants have gained popularity with the aim of prolonging the duration an...
A study of intrathecal bupivacaine with fentanyl and intrathecal bupivacaine with clonidine with respect to sedation and intraoperative and postoperative analgesia in patients undergoing lower abdominal and lower limb surgeries
Background: Spinal anesthesia is a preferred choice of anesthesia in lower abdominal and lower limb surgeries. Various drugs have been used as adjuvants along with bupivacaine for subarachnoid block, but fentanyl and clo...