Dexmedetomidine versus propofol for attenuation of hemodynamic response to creation of pneumoperitoneum in laparoscopic cholecystectomies: A randomised prospective study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 1
Abstract
Background: Creation of pneumoperitoneum has been found to be associated with hemodynamic changes and hence various drugs have been studied to attenuate such response. Aims: To compare the effectiveness of dexmedetomidine and propofol in attenuating the hemodynamic response to pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Materials and methods: Eighty patients of American Society of Anaesthesiologists (ASA) physical status I or II were randomly allocated into two groups to receive dexmedetomidine or propofol infusion after induction of anaesthesia. Hemodynamic parameters (heart rate, Systolic and diastolic blood pressure), duration of pneumoperitoneum, time to extubation were recorded. Statistical analysis was done using students t test and chi-square test and p value<0.05 was considered significant. Results: Both dexmedetomidine and propofol attenuated the hemodynamic response to pneumoperitoneum, but heart rate and systolic blood pressure showed better control in dexmedetomidine group, whereas diastolic blood pressure was comparable between two groups. Total duration of pneumoperitoneum and time to extubation were comparable between the two groups. Conclusion: Dexmedetomidine infusion without loading dose is effective in preventing hemodynamic response to pneumoperitoneum in patients undergoing laparoscopic cholecystectomy and may be better alternative to propofol in such patients.
Authors and Affiliations
Aabid Hussain Mir, Shaista Yaqoob, Ajaiz rasool, Azka Sunain Khan, Showkat A Gurcoo
Keywords
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- EP ID EP589639
- DOI 10.26611/10151017
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