Diabetes Mellitus Relationship with Vitamin D and Vitamin B12 Levels: A Retrospective Analysis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
To compare the levels of vitamin D and vitamin B12 in patients with type 2 diabetes mellitus (DM) versus those without diabetes mellitus. Serum hemoglobin A1c (HbA1c), 25-hydroxy vitamin D, vitamin B12, calcium and phosphate levels were studied in 1932 patients who applied to Adult Endocrinology Unit of Dicle University Medical Faculty Hospital between January 2016 and January 2018 the patients were taken to work and the results were retrospectively reviewed. According to HbA1c levels, two groups were categorized as non-diabetic and diabetic.The results were evaluated according to age, gender and seasonal variables as well as biochemical parameters. In the study group, the patients between 2016 and 2017 were classified as non-diabetic and diabetic according to their HbA1c values, whereas the diabetic patients (%41.04). Diabetic patients (HbA1c level>%6.5) with D vitamin-B12 and D vitamin-calcium were statistically significant (p <0.001) (p <0.001); A negative correlation between vitamin D- phosphorus and vitamin D-HbA1c was statistically significant (p <0.01) (p <0.01).In the statistical evaluation of the hemoglobin A1c (HbA1c) groups, it was seen that in the group of HbA1c> %6,5, vitamin D value was lower in males (p = 0,002) than in females (p = 0,093) and was meaningful in males. There was a statistically negative correlation significant (p <0,01). In the group of HbA1c> %6,5, B12 value (p <0,001) was lower in males than females (p <0,05), both of which were significant. These findings suggest that increased vitamin D deficiency in patients with Type 2 diabetes is important in examining vitamin D and B12 levels in such chronic diseases. The statistical significance of vitamin D in male diabetic patients suggests that this may be due to hormonal differences. Prospective studies are needed to clarify the relationship between vitamin D and vitamin B12 in patients with type 2 diabetes.
Authors and Affiliations
Gülten TOPRAK, İlhan SABANCILAR, Zafer PEKKOLAY, Ahmet DÖNDER
Keywords
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