Diagnosis and Treatment of Conidiobolomycosis: A Review of 75 Cases from the Indian Subcontinent
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
ABSTRACT Introduction: Conidiobolomycosis is a subcutaneous rhinofacialzygomycosis caused by Conidiobolus spp. Its epidemiology in the Indian subcontinent is not well understood. Aim: The aim of this study was epidemiological characterisation of conidiobolomycosis in the Indian subcontinent. Materials and Methods: We conducted a review of literature using the terms “conidiobolomycosis”, “conidiobolus”, “entomophthoramycosis” and “entomophthoromycosis” in the Pubmed database combined with the following: India and publication language (English). Results: A total of 75 cases of conidiobolomycosis were reported from 12 states of India, between October 1966 and December 2017, who presented with centrofacial swelling (males-62, females-13). The mean age of presentation was 35 years. Majority of the patients were immunocompetent with only one patient being immunosuppressed (acute leukaemia). A total of 21 patients were diagnosed only on the basis of culture, while the rest of them were diagnosed either on histopathology alone (n=33) or a combination of histopathology and culture (n=21). Saturated solution of potassium iodide (SSKI) was the most common drug (alone or in combination) used for treatment. Except one mortality, which was unrelated to the disease, all patients (n=56) responded to therapy. Conclusion: Conidiobolomycosis is reported from most parts of the country, primarily in immunocompetent males and has an excellent response to anti-fungals.
Authors and Affiliations
Nitin Gupta, Manish Soneja
Keywords
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- EP ID EP581826
- DOI 10.7860/JCDR/2019/40142.12701
- Views 85
- Downloads 0
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