Diagnostic Role of CSF-ADA in Differential Diagnosis of Meningitis
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Among the patients with meningitis, tubercular meningitis is an important cause of morbidity and mortality in India and other developing countries. Due to lack of early diagnosis, fatality is high in positive cases and sequel of disease may be distressing and disabling in the non-fatal cases. The estimated mortality due to tubercular meningitis in India is 1.5/100,000 population.Many literature has shown that CSF- ADA levels can differentiate various types of meningitis. Aim of the present study was to evaluate whether ADA levels can be used to differentiate various types of meningitis in suspected meningitis cases. Material and methods: A total of 138 clinically suspected cases of meningitis admitted to NSCB medical college hospital Jabalpur were studied. All the cases were examined clinically and their CSF and blood samples were obtained for various investigations after taking consent in written Performa. CSF ADA levels were measured in all cases using Spectrophotometric method. Result: Statistically significant higher values of CSF- ADA were observed with Tubercular Meningitis compared to Pyogenic Meningitis and Viral meningitis cases (p<0.001). The sensitivity and specificity was 96.4% and 96.4% respectively when a cut-off value of ADA of 11U/l was used. The PPV, NPV and accuracy of ADA test in diagnosing Tubercular Meningitis was 97.6, 94.6 and 96.4 respectively. Conclusion: We concluded that CSF- ADA level can be used as simple, rapid, inexpensive test for early diagnosis of tubercular meningitis and differentiating it from pyogenic and viral meningitis.
Authors and Affiliations
Sharad Jain, Anand Sharma, Rashmi Nayak
Keywords
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