Diagnostic significance of various cytomorphological features and their quantification for the diagnosis of papillary carcinoma thyroid on fine needle aspiration cytology
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction The relative reliability of the morphological features for making a diagnosis of PTC when considered independently is debatable Quantification of morphological features has been attempted to improve the diagnostic efficacy of FNA thyroid but universal acceptance is lackingAim This study was aimed to analyze the independent diagnostic significance of the four common morphological featuresNuclear grooves NG Intranuclear cytoplasmic inclusions INCI Papillary Fragments and Metaplastic Cytoplasm in thyroid swellings using a quantitative approachMaterials and Methods Retrospective study including thyroid FNA cases with corresponding histopathological report was analyzed Eighty six cases had at least one of the four morphological features mentioned The cases with NG were categorized into three groups 20 1019 and Results The sensitivity specificity PPV and NPV of NG for PTC in the category of 20 was 533 982 941 and 797 respectively and the same in the category of 10 were 667 75 588 and 808 respectively Specificity and sensitivity of Frequent INCI were 100 and 3667 respectivelyConclusion Typical morphological features of PTC can be seen in nonmalignant conditions as well Occurrence of NG 20 and INCI 5 are highly specific for the diagnosis of PTC Cases with NG between 1019 should be considered as suspicious for malignancy and pathologist should cautiously look for other morphological features Keywords Papillary carcinoma thyroid PTC FNAC Cytology Morphology Quantification
Authors and Affiliations
Chetna Sharma, Babu Jacinth, Vijayakumar Harivanzan
Keywords
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- EP ID EP475943
- DOI 10.18231/2394-6792.2018.0094
- Views 57
- Downloads 0
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