Diagnostic, therapeutic and prognostic implications of the BRAF V600E mutation in cutaneous melanomas
Journal Title: Revista Información Científica - Year 2019, Vol 98, Issue 3
Abstract
Introduction: Melanoma accounts for 4% of all malignant skin tumors, but is responsible for 80% of cancer deaths in this site. The emergence of therapies directed against the BRAF mutation has changed the prognosis, hence the importance of identifying this mutation in patients with histological diagnosis of malignant melanoma since the rate of mutations of the BRAF oncogene is high. Objective: to describe the diagnostic, therapeutic and prognostic implications of the determination of the mutation of the BRAF V600E gene in cutaneous malignant melanoma. Method: literature review via PUBMED with the introduction of the following search terms: melanoma, melanoma AND genetics, melanoma AND BRAF mutation, melanoma AND BRAF V600E AND prognosis. 72 publications were identified. Results: multiple studies have corroborated the high frequency of the mutated BRAF V600E oncogene in cutaneous melanoma, offering the possibility that through the identification of this alteration it can contribute to improve the diagnosis and to guarantee a treatment directed specifically against the activity of BRAF. Conclusions: the identification of the BRAF oncogene mutation represents a prognostic factor and may represent an effective therapeutic target.
Authors and Affiliations
Alberto José Piamo Morales
Keywords
Related Articles
- EP ID EP626388
- DOI -
- Views 49
- Downloads 0
Design of a modality of professional improvement for the early diagnosis of breast cancer
Introduction: The professional overcoming of nursing staff in today's society is a challenge, so it is imperative to constantly prepare the staff who works in Primary Health Care to be able to promote favorable lifestyle...
Need for cost studies at the University of Medical Sciences Guantánamo
Partial results of the Institutional Project "Evaluation of the impact of the methodology for the development of intellectual capital in health services" were presented, in execution by the University of Medical Sciences...
Alzheimer's disease, some modifiable risk factors
Introduction: dementia is a disorder of cognition that interferes with the functioning of daily life and produces a loss of independence. Its prevalence and incidence increase with advanced age. An updated bibliographica...
Guantanamo´s teaching experience of collaborators in the Bolivarian Republic of Venezuela
Introduction: values are part of man's life in the Cuban revolutionaries the value of internationalism, commitment, engagement and solidarity are well rooted from all time in our history, at this point in the homeland of...
Obesity: a challenge for Primary Health Care
Obesity is currently considered a pandemic that is the basis of different health problems that are faced in primary care, which motivated us to carry out this literature review with the aim of deeping into some aspects r...