Diagnostic utility of Adenosine Deaminase in Exudative pleural effusions
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: The objective is to determine the importance of adenosine deaminase (ADA) in exudative pleural effusions of different etiologies. It was an observational study conducted at a tertiary care teaching institute. Out of a total of 50 pleural fluid samples, 35 were found to be exudates and were include in the study. Pleural fluid ADA was done for all included patients. Pleural fluid ADA ≥40 U/l was taken as diagnostic cut off for TB effusion. Sensitivity, specificity positive and negative predictive value of pleural fluid ADA for diagnosing TB was calculated by using clinical calculator – 1, Richard Lowry 2001-2013. There were 35 patients with pleural effusion, out of which 35 (71.8%) were found to be exudative and were studied further. There were 17 (40.1%), 6 (29.5%) and 7(27%) cases of TB, malignancy and para pneumonic effusion respectively, whereas 5(3.3%) cases remained undiagnosed. Median ADA values for TB, malignancy and para pneumonic effusion were 49.8 U/l, 18 U/l and 25 U/l respectively. Conclusion: Pleural fluid ADA remains useful in diagnosing tuberculosis pleural effusion. The median ADA for TB effusion in present cohort was 49.8 IU/ml. Pleural fluid ADA of 40 U/L yielded 89.5% negative predictive value and 75% positive predictive value.Pleural fluid ADA is cost effective and good screening test for diagnosis of TB. Keywords:Adenosine deaminase, pleural effusion, tuberculosis
Authors and Affiliations
Nitish Gupta, Vaibhav Krishna, Dinesh V Reddy
Keywords
Related Articles
- EP ID EP372198
- DOI -
- Views 45
- Downloads 0
Etoposide induced hepatotoxicity- A rare case report
: Seminoma is a malignant germ cell tumor usually affecting the testicles.Treatment usually requires removal of the involved testis. Chemotherapy is recommended for patients with stage IIC or stage III seminomas. Etoposi...
A Preliminary Evaluation of Stool Antigen Test in H. pylori Infections
Abstract: The discovery of Helicobacter pylorirevolutionised the concept of gastroduodenal pathology& diverted the world wide attention from pH to Hp (H. pylori). Surgical management is replaced by antibiotics. Endoscopy...
Nocardia asteroids: A case report of post-operative endophthalmitis
Abstract: Post-operative Nocardia endophthalmitis has an aggressive course and poor visual outcome. The major clinical manifestations of Nocardial endophthalmitis are decreased visual acuity, which usually progressed ove...
An evaluation of knowledge and practice towards radiation protection among radiographers of Agra city
Abstract: Radiation protection among radiographers has gained concern in recent times. The level of awareness concerning with radiation protection influences staff behavior. If they have not enough information related to...
A Study of Haemoglobinopathies by Various Methods
Abstract: Haemoglobinopathies constitute a very important causative factor for anaemias of childhood. The two common haemoglobinopathies widely distributed across our country are the beta thalassemic syndromes and sickli...