Diagnostic value and clinical significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio combined with carbohydrate antigen in endometrial carcinoma
Journal Title: TMR Clinical Research - Year 2020, Vol 3, Issue 1
Abstract
Background: To explore diagnostic value and clinical significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) combined with serum carbohydrate antigen (CA), including CA125, CA153 and CA199, in endometrial cancer (EC). Methods: The clinical data of 135 patients who underwent endometrial pathology examination in our hospital from January 2014 to June 2019 were retrospectively analyzed, including 65 cases of EC, 40 cases of proliferative endometrial lesions and 50 cases of normal endometrium. Blood routine analyzer and electrochemical luminescence method were used to detect 5 parameters of NLR, PLR, CA125, CA153 and CA199 in these patients. The study explored the relationship between the five indicators and different levels of endometrial lesions, and analyzed their relationship with clinical pathological characteristics of EC patients. The diagnostic efficacy of NLR, PLR, CA, NLR combined CA, PLR combined CA was evaluated by receiver operating curve (ROC) combined with logistic regression equation. Results: The expression of the five parameters was different in different levels of endometrial lesions, and the expression level increased with the increase of endometrial lesion level. The difference among the three groups was statistically significant (P < 0.05). CA125 level was related to International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis and ki-67 index. CA153 level was related to ki-67 index. CA199 was related to FIGO stage, tissue differentiation and lymph node metastasis. NLR was related to FIGO stage, pathological type, tissue differentiation, myometrial invasion and lymph node metastasis. PLR was correlated with tissue differentiation, and the differences were statistically significant (P < 0.05). The diagnosis of NLR combined with CA was the largest area under ROC curve (0.940), and its accuracy, sensitivity and specificity were higher than those of individual parameters and NLR combined with CA. Conclusion: NLR, PLR, CA125, CA153 and CA199 were highly expressed in EC and were correlated with clinical pathological data of EC patients respectively. NLR and PLR combined with CA could significantly improve the diagnostic efficiency of EC, providing clinical reference value for EC screening, therapeutic effect evaluation and disease progression evaluation.
Authors and Affiliations
Xing Wang, Ping Han, Yan-Fang He
Keywords
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- EP ID EP678603
- DOI 10.12032/TMRCR20200104001
- Views 207
- Downloads 1
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