DIAGNOSTIC VALUE OF RETICULOCYTE HEMOGLOBIN AND SOLUBLE TRANSFERRIN RECEPTOR IN DETERMINING THE IRON STATUS OF CHRONIC KIDNEY DISEASE WITH HEMODIALYSIS PATIENTS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
Objective: This research aims to find the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the new parameters reticulocyte hemoglobin (Ret-He), and soluble transferrin receptor (sTfR) in determining the iron status of patients with chronic kidney disease with hemodialysis (CKD-HD) who will receive recombinant human erythropoietin (rHuEPO) therapy which requires sufficient iron levels. Methods: The cross-sectional study was conducted in Hemodialysis (HD) Unit of Dr. M. Soewandhie Regional General Hospital from September 2018 to March 2019. Patients with CKD and anemia who had undergone hemodialysis were recruited in this study. There were two groups: Group 1, patients with iron-deficiency anemia and Group 2, patients without iron-deficiency anemia. Examination on Ret-He and sTfR was performed through comparison with gold standard transferrin saturation and ferritin serum. Results: The mean±standard deviation of Ret-He is 30.18±2.74 pg, sTfR of male group is 2704.11±1981 mg/l and sTfR of female group is 3837.76±1415 mg/l. The agreement of Ret-He and gold standard was 85.4% (p=0.000) with sensitivity 86.7%, specificity 84.6%, PPV 76.5%, and NPV 91.7%. The agreement of sTfR in male was 92.8% (p=0.002) with sensitivity 100%, specificity 90.9%, PPV 75%, and NPV 100%. As for female, it was 85.1% (p=0.000), with sensitivity 83.3%, specificity 86.75%, PPV 83.3%, and NPV 86.7%. According to sTfR/log ferritin index calculation, the agreement was 100% (p=0.000) for male and 85.1% (p=0.000) for female. Conclusion: The diagnostic values of the parameters Ret-He, sTfR, and sTfR/log ferritin index were high and therefore can be used to diagnose iron-deficiency anemia in CKD-HD patients who will undergo rHuEPO therapy.
Authors and Affiliations
DWI LILY LUKAS , YETTI HERNANINGSIH , ARI TRIANTANOE
Keywords
Related Articles
- EP ID EP646644
- DOI -
- Views 103
- Downloads 0
FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESSIVE MATRIX TABLETS OF LEVAMISOLE: ASSEMENT OF PURIFIED FRUIT PULP POLYSACCHARIDE ISOLATED FROM AEGLE MARMELOS AS MUCOADHESIVE EXCIPIENT
ABSTRACTObjective: Mucoadhesive tablets have been developed for Levamisole using natural mucoadhesive material such as purified polysaccharide isolated fromthe ripe fruit pulp of Aegle marmelos. Lin (AMPS) and evaluate i...
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVE: DERIVED FROM CIPROFLOXACIN
Objective: The purpose of this research is synthesized and evaluates different derivatives of oxadiazole. Methods: A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine...
EFFECTIVITY ANALYSIS OF NEUROPROTECTOR (VITAMIN B COMPLEX AND MECOBALAMIN) AS NEUROPATHIC PAIN SUPPORTIVE THERAPY IN ELDERLY WITH TYPE 2 DIABETES MELLITUS
Objective: Neuroprotector (Vitamin B complex or mecobalamin)is often used as a supportive neuropathic pain therapy. The effectiveness of this drug remains controversial, especially in geriatrics with Type 2 diabetic neur...
NEUROPROTECTIVE EVALUATION OF LAGENARIA VULGARIS EXTRACT HYPOXIC NEUROTOXICITY INDUCED RATS
ABSTRACTObjective: The present study was aimed to evaluate the neuroprotective effects of Lagenaria vulgaris seed oil (LVSO) in hypoxic neurotoxicity inducedneurodegeneration in mice.Methods: Hypoxia was induced by provi...
PARENTERAL NUTRITION IN NEONATUS AND COMPATIBILITY ISSUES: A REVIEW ARTICLE
Intravenous drug administration in Neonatal Intensive Care Unit is critical because of poor venous access, polymedication, fluid restriction, and lowinfusion rate. Since parenteral nutrition (PN) is infused intravenously...