Dickkopf-1 serum levels in Saudi boys with cerebral palsy and correlations with body mass index and bone turnover markers
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2018, Vol 6, Issue 5
Abstract
Cerebral palsy (CP) is a common disorder in children. Dickkopf-1 (Dkk1) inhibits the canonical Wnt signaling pathway. The study aimed to assess the serum levels of Dkk1 in boys with CP and to evaluate its correlations with body mass index (BMI) and bone turnover markers (BTMs).This study included 32 Saudi boys with different physical disabilities as a result of CP and muscular dystrophy and 39 healthy Saudi boys were enrolled as a control group. The serum levels of Dkk1, N-terminal propeptide of type I collagen (P1NP), bone alkaline phosphatase (B-ALP), and C-terminal cross-linking telopeptide of type I collagen (ß-CTX) were measured using enzyme link immunosorbent assay (ELISA) kits. Serum Dkk1 levels were higher in boys with CP than in controls. Further, level of PINP, TSH, FT4, calcium, and phosphorus were also reported significantly higher in CP boys than in controls. While, level of BMI, ß-CTX, 25-hydroxyvitamin D and PTH were significantly lower in patients than in controls. Serum Dkk1 levels were moderately correlated with calcium (??=0.361, ??=0.0240) in the controls. Dkk1 may play a role in bone loss in boys with CP experiencing weight loss. Dkk1 could aid in the assessment of boys with CP and abnormal bone turnover.
Authors and Affiliations
Zahra Ali AL-Balawi, Hala Salim Sonbol
Keywords
Related Articles
- EP ID EP593086
- DOI 10.18006/2018.6(5).862.870
- Views 53
- Downloads 0
Equine brucellosis: Review on epidemiology, pathogenesis, clinical signs, prevention and control
Brucellosis is one of the major zoonotic diseases that affect several domestic animals, wild animals and also marine mammals. Though there is no specific Brucella sp. that can affect horses, B. abortus and B. suis can af...
EFFECT OF L-PENICILLAMINE, N-ACETYL CYSTEINE AND ?-TOCOPHEROL ACETATE ON BUFFALO (BUBALUS BUBALIS) SPERM KINEMATICS IN VITRO
The post-thaw viability and motility of buffalo sperm are reduced significantly when they are cryopreserved. One of the etiologies of this reduced post-thaw viability and motility of buffalo sperm has been attributed to...
Assessment of genetic purity of inter-specific f1 hybrids involving vigna radiata and vigna umbellata
Genetic purity test of true hybrids from controlled crosses before further generations of selfing or crossing and selection is essential for Mungbean improvement. The present study was conducted to transfer mungbean yell...
A way of reproductive manipulation and biology of Wolbachia pipientis
The endo-symbiotic relationship between microorganism and eukaryotes are very common and has been broadly investigated from all insect species. The genus Wolbachia are obligatory intracellular bacteria that induce evolut...
Effect of management system on nutrient intake and seminal attributes in jamunapari bucks
The present study assessed comparative semen production potential of Jamunapari bucks under stall feeding (SF) and grazing cum supplementation (GS) systems of 10 animals in each system under group feeding and management...