Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach
Journal Title: International Journal of Clinical Endocrinology and Metabolism - Year 2017, Vol 3, Issue 1
Abstract
Background: Dipeptidyl peptidase-IV (DDP-IV) Inhibitors may represent single anti-diabetic drugs, the multiple actions of which may translate into demonstrable therapeutic benefits in diabetes. The marketed synthetic DPP-IV Inhibitors are expensive drugs and have been reported to cause unacceptable adverse effects such as pancreatitis, angioedema, thyroid and pancreatic cancers. In this scenario, research to identify DPP-IV Inhibitors from alternative sources is desirable.
Authors and Affiliations
Mohanty Ipseeta Ray, Kumar Selvaa, Suman Rajesh
Assessment of Prescription Pattern of Antidiabetic Drugs in the Outpatient Department of a Tertiary Care Hospital
Background: Glycemic control remains the major therapeutic objective for prevention of target organ damage and other complications arising from diabetes. Poor glycemic control in diabetes mellitus can be prevented by usi...
Kocher-Debre-Semelaigne Syndrome: Response to Thyroxine Replacement Therapy
Introduction: Congenital hypothyroidism with muscular pseudohypertrophy or Kocher-Debre-Semelaigne syndrome is the result of long standing untreated moderate to severe hypothyroidism. The pathogenesis of this muscular ps...
A Rare Entity Pituitary FDG Uptake; What Should We Expect?
F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is widely accepted modality in order to evaluate the cancer patients for staging, restaging and treatment response evaluation. The i...
Diagnosis and management of primary hypothyroidism in Traditional Chinese Medicine (TCM) and Traditional Indian Medicine (Ayurveda)
Primary hypothyroidism is one of the most common endocrine disorders. TCM and Ayurveda are the two giant ancient systems of medicine flourished in China and Indian sub-continent respectively. The term like hypothyroidism...
Familial Goiter and Related Disorders
Synthesis, storage, secretion, delivery, and utilization of thyroid hormones are dependent upon specific enzymatic activity; inherited disorders may cause thyroid disease. Studies of a cretinous patient from consanguine...