Dislipidemia and systemic inflammation in HIV-infected patients against combined antiretroviral therapy
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
There were screened 142 HIV-infected patients receiving combined antiretroviral therapy (сART) for at least 6 months and who reached a level of viral load (HIV-RNA) less than 50 copies/ml and without clinical manifestations of cardiovascular disease. The study did not include patients with acute inflammation, the number of CD4 + T lymphocytes less than 200 cells/ml, patients with drug addiction and alcoholism. The aim of the study was to establish the severity of dyslipidemia and systemic inflammation in HIV-infected patients, depending on the level of CD4 + T-lymphocytes. It has been established that among patients with HIV receiving сART for a long time, a highly aterogeneic dyslipidemia IIb according to the classification D. Fredrickson develops. Negative prognosis for the course of atherosclerosis in this category of patients is confirmed by a high concentration of С-reactive protein (CRP). An effective сART promotes the reduction of levels of total cholesterol, triglycerides and atherogenicity index against the background of increased high density lipoproteins. At the same time, the concentration of low density lipoproteins does not change and the level of CRP does not decrease sufficiently, which indicates to an unfavorable prognosis for the risk of atherosclerosis progression and cardiovascular complications in HIV-infected patients.
Authors and Affiliations
V. A. Vasylenko
Keywords
Related Articles
- EP ID EP294895
- DOI 10.26641/2307-0404.2018.1(part1).127203
- Views 94
- Downloads 0
Management of patent ductus arteriosus in premature infants
Closure of hemodynamically significant patent ductus arterios (HSPDA) is one of the most important questions in modern neonatal intensive care, especially for preterm babies. Long-term functioning of the hemodynamically...
Характеристика мікроциркуляторного русла яєчок щурів, опромінених електромагнітним полем і вживавших імуномодулятор
Характеристика микроциркуляторного русла яичек крыс, облученных электромагнитным полем и употреблявших иммуномодулятор. Шарапова Е.Н. В результате полученных исследований установлены морфофункциональные отличия в структ...
Anton Chekov and his literary works as sources of studying humanism in medicine
This article is devoted to a well-known doctor and writer A.P. Chekhov. It shows the influence of his doctor's activity on the creative literary process and concept of humanism in his literary works.
Клинический случай осложненного течения гриппа штамма А/H3N2 в эпидемиологическом сезоне 2017-2018 гг.
Клінічний випадок ускладненого перебігу грипу штаму А/H3N2 в епідеміологічному сезоні 2017 -2018 р.р. Черниловський А.В., Болтянський С.В., Пешкова В.О. У статті представлена інформація про перебіг грипу штаму H3N2 у чо...
Критерії порушень життєдіяльності як методична основа визначення інвалідності
Критерии нарушений жизнедеятельности как методическая основа определения инвалидности. Науменко Л.Ю., Борисова И.С., Березовский В.Н. Фесенко Г.Д., Зуб Т.А., Чуб Д.И. Оценка функционального состояния пациента является о...