Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 10
Abstract
Objective To provide foundational data for exploring the association between KIR genes and diseases by analyzing the frequency and polymorphism of killer-cell immunoglobulin-like receptor (KIR) genes in Han, Manchu and Korean populations in Jilin Province. Methods KIR gene typing was performed on 129 Manchu, 198 Korean and 201 Han individuals from Jilin using the polymerase chain reaction-sequence specific primers (PCR-SSP) technique. Results KIR3DL2, KIR3DL3, KIR3DP1 and KIR2DL4 were detected in all subjects. KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1 and KIR2DP1 genes had high detection frequencies, ranging from 93% to 98% across the three ethnic groups. In contrast, the detection rates of KIR2DL2, KIR2DL5, KIR3DS1, KIR2DS1, KIR2DS2, KIR2DS3 and KIR2DS5 were lower, ranging from 13% to 45%. Notably, the detection frequencies of KIR2DL5 (17.83%) and KIR2DS1 (17.83%) in the Manchu population were significantly lower than those in the Korean (42.93%, 47.47%) and Han (33.83%, 33.33%) populations in Jilin. The detection frequencies of KIR2DL5 (42.93%) and KIR2DS1 (47.47%) were significantly higher in the Korean population compared to the Han (33.83%, 33.33%) and Manchu (17.83%, 17.83%) population. The frequency of the KIRAA haplotype in the Han population was the highest among the three ethnic groups in Jilin at 61.19%, significantly higher than that in the Korean population (42.93%). Differences between the three groups were statistically significant (P<0.05), and remained significant after Bonferroni correction (Pc<0.05). Conclusion The distribution of KIR genes in the Korean, Manchu and Han population in Jilin reflects the polymorphism of KIR genes in the Chinese population and also showcases unique ethnic genetic and regional characteristics.
Authors and Affiliations
Yu HAN, Fan YANG, Lingling LIU, Tingting NIE, Xu YANG, Lixin JIAO
Keywords
Related Articles
- EP ID EP749836
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.10.007
- Views 42
- Downloads 0
Intraoperative cell salvage in cesarean delivery of women with placenta previa:a meta-analysis
Objective To systematically evaluate the safety and efficacy of intraoperative cell salvage (IOCS) for placenta previa women undergoing cesarean section. Methods The PubMed, Web of Science, Embase, the Cochrane Library o...
Study on the production efficiency of platelet components in 24 prefecture-level blood stations in China
Objective To learn the production efficient of platelet components among prefecture-level blood stations in China, to provide supporting data for those blood stations to optimize the production mode of platelet component...
Causes of ABO forward and reverse grouping discrepancy: 75 cases
Objective To analyze the causes and solutions of ABO forward and reverse grouping discrepancy, and to ensure the safety of blood transfusion in clinical. Methods Samples from 75 patients with discrepancy between forward...
Analysis and evaluation of platelet bank establishment strategy from the perspective of donor loss
[Objective] To analyze the loss rate of platelet donors and evaluate the strategies for establishing a platelet donor bank. [Methods] A total of 1 443 donors who joined the HLA and HPA gene donor bank for platelets in He...
Detection of platelet bacteria based on cultomics and metagenomics
Objective To explore the composition of culturable bacteria in platelets through bacterial culturomics and verify the results of culturomics and metagenomics to improve the detection rate of bacteria in platelets. Method...