Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Journal Title: Sultan Qaboos University Medical Journal - Year 2003, Vol 5, Issue 1
Abstract
Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
Authors and Affiliations
Musbah O. M. Tanira| Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Mehmet Simsek| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Khalid Al Balushi| Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Khulood Al Lawatia| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Hameedah Al Barawani| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Riad A. Bayoumi| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman
Keywords
Related Articles
- EP ID EP13667
- DOI -
- Views 365
- Downloads 16
Interpreting Neonatal Growth Parameters in Oman Are we doing it right?
Objectives: Tis study aimed to compare reference anthropometric measures of Omani neonates with the international standard growth charts of the World Health Organization (WHO) in order to determine the appropriateness...
Clinical and Laboratory Manifestations of Yemeni Patients with Systemic Lupus Erythematosus
Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multi-systemic involvement. Tis is the frst study undertaken to determine the relationships between serological marker pos...
The Controversies of Hyponatraemia in Hypothyroidism Weighing the evidence
Hyponatraemia is a common electrolyte disturbance, with moderate (serum sodium: 125–129 mmol/L) to severe (serum sodium: ≤125 mmol/L) forms of the disease occurring in 4–15% of hospitalised patients. While it is...
University of the twentyfirst century: Opportunities and challenges for medical education
March 2001 saw an important conference being held in Muscat, heralding signifi cant changes in higher education in Oman and in the Arabian Gulf region in general. With the theme The University of the 21st Century, the Co...
Lifestyle Habits Diet, physical activity and sleep duration among Omani adolescents
Objectives: Tis study aimed to investigate the lifestyle habits—physical activity (PA), eating habits (EH), and sleep duration (SD)—of Omani adolescents, and to examine gender differences in such variables. Methods...