Does Glut-1 and Maspin Expression Have Prognostic Value in Uterine Cervical Carcinomas

Abstract

Aim: Cervical cancer is the the most common gynecologic malignancy worldwide with approximately 750,000 new cases annually. The aim of this study was to pose the histopathologic and clinical features of cervical carcinoma, as well as, the immunohistochemical expression of glucose transporter 1 (GLUT-1) and maspin, and their association with clinicopathological parameters in these cases and whether this relationship is effective with prognosis and survival. Methods: 114 patients were included in this study with the diagnosis of cervix carcinoma between 1992-2012. Tissue microaaray was performed and taken sections immunstained with GLUT-1 and maspin. The relationship is investigated between findings and prognostic factors, local recurrence, distant metastasis and survival. Results: Tumor type, lymph node invasion, and lymphovascular invasion (LVI) and clinic parameters like recurrence and metastasis have not show statistically significant difference with the presence of GLUT-1 and maspin immunreactivity. However, the relationship between maspin expression and stage shows statistically significant difference (p = 0.048) indicating that the higher expression of maspin is correlated with lower stages. Conclusion: In our study we observed that the presence of maspin expression and stage have shown statistically significant difference but we could not detect the same difference between GLUT-1 presence and stage. Also we did not find any correlation between GLUT-1 and maspin expression with the factors which are mentioned in the literature that affect prognosis and survival like stage, tumor type, lymph node status, LVI, involvement of parametrium.

Authors and Affiliations

Yasemen Adali

Keywords

Related Articles

A Conventional Approach Towards Regaining Space Using Fixed Open Coil Spring: A Case Report.

Space loss due to premature loss of deciduous teeth, especially second deciduous molar, can lead to mesial migration of the first permanent molar, disturb the integrity of arch resulting in space loss. Literature has sho...

Results of Proximal Fibular Osteotomy for Medial Joint Space Osteoarthritis Knee

Arthritis is the most common cause of disability in the older population whether its about lage joints [shoulder joint, knee joint, hip joint etc] or small joints. Disability is mainly caused by pain...

The Study of Association of Urogenital Infections as a Risk Factor for Spontaneous Preterm Labour 1Dr.M.S.Sornam, 2Dr.N.Agila Raththi, 3S.Padmanaban

Background Prematurity is the condition where the fetus enters the extra uterine life with biological immaturity. Maturation is defined as the process of completing full development or growth [1]. The embryo and fetus m...

Melanotic Neuroectodermal Tumour of Infancy- A Short Communication

Melanotic Neuroectodermal tumour of infancy is rare occurring in infants less than one year old. Early diagnosis with prompt treatment is desirable as it can take malignant transformation. Surgical excision being the tre...

Study of dyslipidemia in Type 2 Diabetes Mellitus and its correlation with glycemic parameters

Introduction: Diabetes Mellitus (DM), caused by relative or definite insulin deficiency or by insulin resistance is a progressive chronic disease leading to hyperglycemia, characterized by disorders of carbohydrate, lipi...

Download PDF file
  • EP ID EP519662
  • DOI -
  • Views 129
  • Downloads 0

How To Cite

Yasemen Adali (2018). Does Glut-1 and Maspin Expression Have Prognostic Value in Uterine Cervical Carcinomas. International Journal of Medical Science and Innovative Research (IJMSIR), 3(10), 190-201. https://europub.co.uk./articles/-A-519662