Dose dependent Effect of Intrathecal Dexmedetomidine with Bupivacaine in Infraumblical Surgeries
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Various intrathecal adjuvants are being used with local anesthetics for prolongation of intraoperative and postoperative analgesia. Dexmedetomidine (DMT), a highly selective alpha-2 adrenergic agonist is a new neuraxial adjuvant gaining popularity. The study included 60 ASA class I and II patients undergoing infra umbilical surgery under spinal anesthesia. The patients were randomly allocated into three groups (20 patients each).Each group recieved 4 µgm, 6µgm, and 8 µgm of DMT with 3 ml of bupivacaine respectively. The onset time to reach peak sensory and motor level, duration of sensory and motor block, duration of postoperative analgesia, hemodynamic changes, and side effects were recorded. Result -Onset of sensory and motor blocks were similar in all 3 groups. There was a significant and dose-dependent prolongation of duration of sensory block (190.7+/-21.37, 211.05+/-13, 238.15+/-21.53 min (p.00159<0.05) Duration of motor block (319+/-25.25, 350.42+/-16, 390.7+/-33.55 min p.000267<0.05 and duration of analgesia (442.8+/-34.96, 475.25+/-34.44, 611.58+/-35.46 min (p.0000001<0.05) with escalating doses of DMT. Conclusions: There is significant prolongation in duration of motor block, sensory block and analgesia without any significant adverse effect, with increasing doses of intrathecal DMT added to 0.5% bupivacaine
Authors and Affiliations
Sapna Singh, B L Mathur, Neena Rungta
Keywords
Related Articles
- EP ID EP369875
- DOI 10.9790/0853-1703146872.
- Views 69
- Downloads 0
Dreadful Complications If Diabetes in Pregnancya Case Report
Abstract: In INDIA diabetes is on rise. Diabetes is associated with maternal and perinatal morbidity and mortality. The number of pregnant women with pre-existing diabetes is increasing. . Overall, type 1 diabetes accoun...
Study of Thyroid Profile in women with Abnormal Uterine Bleeding
Introduction: Thyroid gland is the most vital endocrine organ which plays a major role in growth, development, metabolism and function of almost every organ of the body. Both Hypo and Hyperthyroidism can cause menstrual...
MTA: A review of literature with clinical applications
Mineral trioxide aggregate (MTA) is a calcium silicate-based cement. It has remained a widereaching material in endodontics since its introduction in the 1990’s. Several studies have illustrated its use in various clinic...
Osteosynthesis of Radialhead Fractures
Radialhead is an important stabilizer of the elbow joint. Radialhead fractures are most common fractures of elbow joint. We intended to follow up the functional outcome of newly designed pre - contoured plates and herbet...
Prospective observational Study: Role of Vitamin D in Sick Newborn
Objective: To study whether the newborn are having vitamin D deficiency or not , whether their vitamin d level is related to morbidity of newborn or not and their correlation with mother. Methods: This study included 350...