Double Trouble: an observational study of thyroid dysfunction in South Indian subjects with type 2 diabetes
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 2
Abstract
Objective: Studies conducted in subjects with type 2 diabetes have shown increased prevalence of overt hypothyroidism and subclinical hypothyroidism. Hence, we designed a study to find out the prevalence of thyroid dysfunction in south Indian subjects with type 2 diabetes. Research Design and Methods: 400 subjects with type 2 diabetes attending the out-patient department of Karnataka Institute of Endocrinology and Research, Bangalore were randomly selected. 200 relatives who accompanied the subjects without diabetes were recruited as controls. BMI, waist circumference, blood pressure, fasting plasma glucose, post prandial plasma glucose, HbA1c, lipid profile, and thyroid profile of these subjects were determined. Results: 400 subjects with type 2 diabetes and 200 subjects without diabetes were included in the study. They were in the age group of 25 to 75 years. Thyroid dysfunction was present in 13% of non diabetic controls. Subclinical hypothyroidism was present in 7%, overt hypothyroidism in 5% and hyperthyroidism in 1% of the controls. Thyroid dysfunction was present in 24% of subjects with type 2 diabetes. Subclinical hypothyroidism was present in 11.25%, overt hypothyroidism in 12% and hyperthyroidism in 0.75% of the 400 subjects with type 2 diabetes. Conclusions: Hypothyroidism especially subclinical hypothyroidism is more common in south Indian subjects with type 2 diabetes. Hence, it is indispensable to investigate for thyroid dysfunction in subjects with type 2 diabetes. Failure to recognize the presence of thyroid dysfunction may be a primary cause of poor glycemic control often encountered in some subjects with type 2 diabetes, despite appropriate anti diabetic therapy. This highlights the need for the routine evaluation of thyroid function in subjects with type 2 diabetes.
Authors and Affiliations
R. Anil Kumar, R Lalitha, Surekha B. Shetty
Keywords
Related Articles
- EP ID EP265615
- DOI 10.17511/ijmrr. 2017.i02.10
- Views 111
- Downloads 0
hsTropI: an early biomarker of acute coronary syndrome & MI
In the Emergency Department cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction (MI) and are useful for risk stratification of patients with acute coronary syndrome (ACS) and s...
The diagnostic utility of FNAC in palpable lesions of breast at a tertiary care centre
Background: Breast lumps constitute a significant proportion of surgical cases in both developed and developing countries. Fine Needle Aspiration Cytology (FNAC) is a simple, minimally invasive, cost effective, outpatien...
To compare the outcome of intramedullary nailing and locking compression plate fixation in treatment of proximal one third tibia fracture: A randomized control trial
Background: Fractures of tibia shaft are most common of long bone fractures. Proximal tibia fractures account for approximately 5% to 11% of all tibial injuries and affect knee function and stability in most of the cases...
Study of socio-demographic profile and contraceptive use among married women attending an Urban Health Centre, Berhampur
Introduction: The higher fertility in India is attributed to early marriage, low level of literacy, poor level of living, limited use of contraceptives and traditional ways of life. Family planning plays a key role in de...
Histopathology of fallopian tubes: a study in the age group of 35 – 50 years in a metropolis of Eastern India
Introduction: Diseases of fallopian tubes are not very commonly described in world literature. However they very commonly form surgical specimen in various treatment modalities of females. Hence it appears prudent enough...