Drug-induced hemolysis due to ceftriaxone: a case report of rare adverse reaction
Journal Title: Perspectives In Medical Research - Year 2014, Vol 2, Issue 2
Abstract
Introduction: Ceftriaxone, a third generation cephalosporin is the commonest antibiotic of choice in any tertiary care hospital. Drug-induced Immune hemolytic anemia is uncommon adverse effect of ceftriaxone. A 52 year old diabetic woman presented to surgical outpatient department with fever and cellulitis of left foot since one week. Patient was started on intravenous ceftriaxone, 1 gram 12 hourly. She complained of chest pain, breathlessness, rash, chills and peri-oral tingling sensation. Her hemoglobin was dropped down to 8.2 g/dl within 24 hours. Peripheral smear showed marked polychromasia, nucleated RBC’s, schistocytes and neutrophilia. A diagnosis of ceftriaxone induced hemolysis was made and the drug was stopped immediately. Dexamethasone was given and intravenous ciprofloxacin was started. Three units of packed cells were transfused and her hemoglobin increased to 10.4 g/dl, at the time of discharge, ten days later. Ceftriaxone-induced hemolysis is a rare, sometimes fatal adverse reaction and the physicians should be aware of it and be vigilant while prescribing this drug.
Authors and Affiliations
Sudhir Kumar Vujhini
Keywords
Related Articles
- EP ID EP295576
- DOI -
- Views 127
- Downloads 0
Vagal nerve Schwannoma
Introduction :Schwannoma arising from the Vagus nerve is an uncommon (2–5%) benign nerve tumour. This tumour most often presents as a slow growing asymptomatic solitary neck mass which rarely undergoes malignant transfor...
A Clinical Study of Fissure in Ano at Tertiary Center in North Telangana
Introduction: An anal fissure is a distressing problem faced by a patient. It is one of the commonest painful anal condition. It is relatively simple to treat with rewarding results. However, disastrous consequences can...
Cervico – Thoracic Vertebral Synostosis
Background: The embryologic development of the human spine is an enormously complex regulated process. In the embryonic life, differentiation and re-segmentation of the sclerotomes is very important. Any abnormality duri...
Small cell carcinoma of prostate
Introduction: Small cell carcinoma(SCC) of prostate is a very rare and highly aggressive neoplasm which constitutes less than 1 % of all prostate cancers. Half of the small cell carcinomas arising in the prostate are pur...
Study of various histopathological types of malignant lesions of Thyroid
Background : Thyroid gland is unique among the endocrine glands in having a wide spectrum of diseases ranging from functional enlargements, immunologically mediated enlargements to neoplastic lesions .Thyroid cancers acc...