Drug Safety Evaluation of Micro Encapsulated Astaxanthin for Sustained Drug Release
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Astaxanthin is a reddish pigment that belongs to a group of chemical called carotenoids. It occur naturally in certain algae and causes the pinkish red color in salmon, trout, lobster, shrimp and other seafood. It may be used as feed supplement and food coloring additive for salmon, crab, shrimp and chicken. It also may a role in treating various diseases like cancer, Alzheimer’s disease, Parkinson’s disease, diabetics etc., Hence, standardization of both microencapsulated and non-encapsulated astaxanthin drug is necessary before testing it in DEN induced mice. Astaxanthin was encapsulated using different compound like sodium alginate, calcium chloride, liposomes, chitosan and TPP. Drug standardization and qualitative analysis of heavy metals in test samples were performed. Overall result shows that microencapsulated and non-encapsulated astaxanthin drug have good quality and purity. Further, it can be used against in vitro and in vivo hepatocellular carcinoma in mice.
Authors and Affiliations
V. Suganya, M. Syed Ali, P. Sangeetha
Keywords
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